INT224529

Context Info Confidence 0.70 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 16 Disease Relevance 12.75 Pain Relevance 1.81

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)

Anatomy Link Frequency articular cartilage 8 cartilage 4 ears 4 chondrocytes 3 mast cells 2 Enpp1 (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 152 98.00 dexamethasone 36 93.40 cytokine 79 90.48 addiction 3 62.68 Kinase C 42 56.84 adenocard 20 49.32 Inflammation 124 45.64 Immobilon 1 22.60 Inflammatory response 9 7.32 chemokine 101 5.00

Disease Link Frequency Relevance Heat Anaphylaxis 153 100.00 Calcification 461 99.72 Aging 133 98.72 Chondrocalcinosis 42 98.20 Osteoarthritis 152 98.00 Disease 103 97.48 Hypersensitivity 136 95.44 Edema 63 85.36 Congenital Anomalies 30 83.76 Asthma 44 59.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This support mechanism becomes dysregulated in aging cartilage, where extracellular PPi excess, mediated in part by upregulated NPP1 expression stimulates calcification.

Positive_regulation (upregulated) of Gene_expression (expression) of NPP1 in cartilage associated with calcification and aging

1) Confidence 0.70 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2254483 Disease Relevance 0.29 Pain Relevance 0

Osteoblasts and chondrocytes have particularly high levels of both NPP1 expression and NPP specific activity [19, 46, 47].

Positive_regulation (levels) of Gene_expression (expression) of NPP1 in chondrocytes

2) Confidence 0.70 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.69 Pain Relevance 0.11

induces both NPP1 expression and elevation of extracellular PPi [12, 31, 43].

Positive_regulation (elevation) of Gene_expression (expression) of NPP1

3) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.62 Pain Relevance 0.13

induces both NPP1 expression and elevation of extracellular PPi [12, 31, 43].

Positive_regulation (induces) of Gene_expression (expression) of NPP1

4) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.62 Pain Relevance 0.13

This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.

Positive_regulation (/) of Gene_expression (expression) of PC-1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis

5) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.65 Pain Relevance 0.28

This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.

Positive_regulation (defective) of Gene_expression (expression) of NPP1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis

6) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.66 Pain Relevance 0.28

This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.

Positive_regulation (defective) of Gene_expression (expression) of PC-1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis

7) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.66 Pain Relevance 0.28

This support mechanism becomes dysregulated in aging cartilage, where extracellular PPi excess, mediated in part by upregulated NPP1 expression stimulates calcification.

Positive_regulation (upregulated) of Gene_expression (expression) of NPP1 in cartilage associated with calcification and aging

8) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2254483 Disease Relevance 0.29 Pain Relevance 0

This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.

Positive_regulation (/) of Gene_expression (expression) of NPP1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis

9) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.65 Pain Relevance 0.28

mol of p-NPTMP for nucleotide pyrophosphatase phosphodiesterase (NPPase) activity or for 2.5 hours with 5 ?

Positive_regulation (mol) of Gene_expression (activity) of NPP

10) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.03

Osteoblasts and chondrocytes have particularly high levels of both NPP1 expression and NPP specific activity [19, 46, 47].

Positive_regulation (levels) of in Osteoblasts Gene_expression (expression) of NPP1 in chondrocytes

11) Confidence 0.24 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.69 Pain Relevance 0.11

Effects of beta-escin after different periods of pre-treatment in the murine PCA model

Positive_regulation (murine) of Gene_expression (model) of PCA associated with anaphylaxis

12) Confidence 0.06 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.85 Pain Relevance 0.08

To initiate the PCA reaction, 2.5 ?

Positive_regulation (initiate) of Gene_expression (reaction) of PCA associated with anaphylaxis

13) Confidence 0.06 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.51 Pain Relevance 0.09

However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?

Positive_regulation (with) of in mast cells Gene_expression (reactions) of PCA in ears associated with anaphylaxis

14) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0

However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?

Positive_regulation (dependent) of Gene_expression (reactions) of PCA in ears associated with anaphylaxis

15) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0

However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?

Positive_regulation (engrafted) of in mast cells Gene_expression (reactions) of PCA in ears associated with anaphylaxis

16) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0

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