INT224529

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 12.75
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
articular cartilage 8
cartilage 4
ears 4
chondrocytes 3
mast cells 2
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 152 98.00 Very High Very High Very High
dexamethasone 36 93.40 High High
cytokine 79 90.48 High High
addiction 3 62.68 Quite High
Kinase C 42 56.84 Quite High
adenocard 20 49.32 Quite Low
Inflammation 124 45.64 Quite Low
Immobilon 1 22.60 Low Low
Inflammatory response 9 7.32 Low Low
chemokine 101 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 153 100.00 Very High Very High Very High
Calcification 461 99.72 Very High Very High Very High
Aging 133 98.72 Very High Very High Very High
Chondrocalcinosis 42 98.20 Very High Very High Very High
Osteoarthritis 152 98.00 Very High Very High Very High
Disease 103 97.48 Very High Very High Very High
Hypersensitivity 136 95.44 Very High Very High Very High
Edema 63 85.36 High High
Congenital Anomalies 30 83.76 Quite High
Asthma 44 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This support mechanism becomes dysregulated in aging cartilage, where extracellular PPi excess, mediated in part by upregulated NPP1 expression stimulates calcification.
Positive_regulation (upregulated) of Gene_expression (expression) of NPP1 in cartilage associated with calcification and aging
1) Confidence 0.70 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2254483 Disease Relevance 0.29 Pain Relevance 0
Osteoblasts and chondrocytes have particularly high levels of both NPP1 expression and NPP specific activity [19, 46, 47].
Positive_regulation (levels) of Gene_expression (expression) of NPP1 in chondrocytes
2) Confidence 0.70 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.69 Pain Relevance 0.11
induces both NPP1 expression and elevation of extracellular PPi [12, 31, 43].
Positive_regulation (elevation) of Gene_expression (expression) of NPP1
3) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.62 Pain Relevance 0.13
induces both NPP1 expression and elevation of extracellular PPi [12, 31, 43].
Positive_regulation (induces) of Gene_expression (expression) of NPP1
4) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.62 Pain Relevance 0.13
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Positive_regulation (/) of Gene_expression (expression) of PC-1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
5) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.65 Pain Relevance 0.28
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Positive_regulation (defective) of Gene_expression (expression) of NPP1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
6) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.66 Pain Relevance 0.28
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Positive_regulation (defective) of Gene_expression (expression) of PC-1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
7) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.66 Pain Relevance 0.28
This support mechanism becomes dysregulated in aging cartilage, where extracellular PPi excess, mediated in part by upregulated NPP1 expression stimulates calcification.
Positive_regulation (upregulated) of Gene_expression (expression) of NPP1 in cartilage associated with calcification and aging
8) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2254483 Disease Relevance 0.29 Pain Relevance 0
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Positive_regulation (/) of Gene_expression (expression) of NPP1 in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
9) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.65 Pain Relevance 0.28
mol of p-NPTMP for nucleotide pyrophosphatase phosphodiesterase (NPPase) activity or for 2.5 hours with 5 ?
Positive_regulation (mol) of Gene_expression (activity) of NPP
10) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.03
Osteoblasts and chondrocytes have particularly high levels of both NPP1 expression and NPP specific activity [19, 46, 47].
Positive_regulation (levels) of in Osteoblasts Gene_expression (expression) of NPP1 in chondrocytes
11) Confidence 0.24 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.69 Pain Relevance 0.11
Effects of beta-escin after different periods of pre-treatment in the murine PCA model
Positive_regulation (murine) of Gene_expression (model) of PCA associated with anaphylaxis
12) Confidence 0.06 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.85 Pain Relevance 0.08
To initiate the PCA reaction, 2.5 ?
Positive_regulation (initiate) of Gene_expression (reaction) of PCA associated with anaphylaxis
13) Confidence 0.06 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.51 Pain Relevance 0.09
However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?
Positive_regulation (with) of in mast cells Gene_expression (reactions) of PCA in ears associated with anaphylaxis
14) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0
However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?
Positive_regulation (dependent) of Gene_expression (reactions) of PCA in ears associated with anaphylaxis
15) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0
However, at 6 h after antigen challenge, IgE-dependent PCA reactions in ears that had been engrafted with CCRL2 KO mast cells contained ?
Positive_regulation (engrafted) of in mast cells Gene_expression (reactions) of PCA in ears associated with anaphylaxis
16) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0

General Comments

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