INT224530

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 7.03
Pain Relevance 5.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
mast cell 3
osteoblasts 1
lumen 1
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Patient controlled alalgesia 105 100.00 Very High Very High Very High
Morphine 75 100.00 Very High Very High Very High
dexamethasone 36 98.22 Very High Very High Very High
Analgesic 25 98.16 Very High Very High Very High
Pain 166 97.32 Very High Very High Very High
Perioperative pain 85 91.76 High High
Pain management 40 91.40 High High
Inflammation 112 91.04 High High
depression 8 90.52 High High
Pain score 30 89.56 High High
Disease Link Frequency Relevance Heat
Anaphylaxis 153 100.00 Very High Very High Very High
Disease 55 99.72 Very High Very High Very High
Calcification 185 99.70 Very High Very High Very High
Pain 246 97.32 Very High Very High Very High
Edema 63 93.52 High High
Post Operative Pain 90 91.76 High High
INFLAMMATION 121 91.04 High High
Depression 8 90.52 High High
Hypersensitivity 136 89.12 High High
Contact Dermatitis 21 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of NPP1 but not NPP3 is associated with calcification by chondrocytic cells in situ and in vitro [12, 31].
Positive_regulation (Upregulation) of NPP1 associated with calcification
1) Confidence 0.70 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.75 Pain Relevance 0.12
1 stimulated NPPase activity by 5-fold at 24 hours (Figure 2b).
Positive_regulation (stimulated) of NPP
2) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
Osteopontin expression was depressed and procalcifying alkaline phosphatase specific activity and calcification were markedly upregulated in cultured NPP1-/- SMCs [35].
Positive_regulation (upregulated) of NPP1 associated with calcification
3) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.51 Pain Relevance 0
In cells such as osteoblasts and chondrocytes that normally express NPP1 relatively robustly, NPP1 and NPP3 increase intracellular PPi, suspected to be in large part in the lumen of the ER and Golgi [12, 16, 31].
Positive_regulation (increase) of NPP1 in lumen
4) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.32 Pain Relevance 0.05
Furthermore, the marked depletion of extracellular PPi and of osteopontin, the rapid, extensive calcification by both NPP1-/- and ank/ank osteoblasts in culture are corrected by soluble NPP1, reinforcing a central role of NPP1 in skeletal PPi and Pi metabolism and osteopontin expression [18], a notion strongly supported by in vivo studies [21, 33].
Positive_regulation (role) of NPP1 in osteoblasts associated with calcification
5) Confidence 0.50 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.42 Pain Relevance 0.05
Other estimates of PCa/PNa are in the range of 1.2 to 4.2 (3, 4, 9, 16), although there are methodological differences in these studies.
Positive_regulation (estimates) of PCa
6) Confidence 0.49 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0.07
Hairless SKH1-mice, female, 10 weeks old, were pre-treated i.p. with beta-escin, dexamethasone (3 mg/kg) or vehicle (NaCl or PBS, 10 ml/kg) at different dosages and time points prior induction of a PCA reaction as indicated in the text and figure legends.
Positive_regulation (induction) of PCA associated with anaphylaxis and dexamethasone
7) Confidence 0.09 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.62 Pain Relevance 0.09
To determine the influence of the pre-treatment period on the PCA reaction, mice were injected with 3 mg/kg beta-escin 1, 2, 3 or 6 h before induction of PCA (Figure 2).
Positive_regulation (induction) of PCA associated with anaphylaxis
8) Confidence 0.09 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.85 Pain Relevance 0.05
A higher VAS score on POD 1 was associated with a higher total PCA morphine use for the entire hospitalization.
Positive_regulation (use) of PCA associated with patient controlled alalgesia and morphine
9) Confidence 0.06 Published 2010 Journal Eplasty Section Body Doc Link PMC2941188 Disease Relevance 0.19 Pain Relevance 1.00
A subgroup of patients (25.1%) continued to require PCA usage on the third postoperative day.
Positive_regulation (require) of PCA associated with patient controlled alalgesia
10) Confidence 0.06 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2941188 Disease Relevance 0.79 Pain Relevance 1.50
When analyzing the PCA usage over the first 3 PODs (Fig 2), most patients (134, 74.8%) required PCA usage only in the first 2 days and were quickly converted to oral pain medication.
Positive_regulation (required) of PCA associated with pain and patient controlled alalgesia
11) Confidence 0.06 Published 2010 Journal Eplasty Section Body Doc Link PMC2941188 Disease Relevance 0.19 Pain Relevance 0.91
However, a small group of patients (45, 25.1%) was identified, which continued to require PCA usage on the POD 3.
Positive_regulation (require) of PCA associated with patient controlled alalgesia
12) Confidence 0.06 Published 2010 Journal Eplasty Section Body Doc Link PMC2941188 Disease Relevance 0.18 Pain Relevance 0.98
Analysis of the data demonstrated that on the POD 3 the majority of patients no longer required PCA.
Positive_regulation (required) of PCA associated with patient controlled alalgesia
13) Confidence 0.06 Published 2010 Journal Eplasty Section Body Doc Link PMC2941188 Disease Relevance 0.52 Pain Relevance 0.89
Mast cell–expressed CCRL2 is required for optimal induction of IgE-dependent PCA
Positive_regulation (dependent) of PCA in Mast cell associated with anaphylaxis
14) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.47 Pain Relevance 0.08
IgE-dependent PCA reactions were associated with a marked reduction in the numbers of dermal mast cells that could be identified in histological sections of these sites based on the staining of the cells' cytoplasmic granules (Fig. 4 C), an effect which most likely reflected extensive mast cell degranulation at these sites (35, 36).
Positive_regulation (dependent) of PCA in mast cells associated with anaphylaxis
15) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.51 Pain Relevance 0
This clearly shows that mast cell expression of CCLR2 is not required for elicitation of IgE-dependent PCA but may substantially enhance reactions elicited under conditions where IgE may be limiting.
Neg (not) Positive_regulation (required) of PCA in mast cell associated with anaphylaxis
16) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.71 Pain Relevance 0.04

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