INT224534

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.47
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ankh) plasma membrane (Ankh) molecular_function (Ankh)
cellular_component (Ankh) biological_process (Ankh)
Anatomy Link Frequency
chondrocytes 2
Ankh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 168 98.08 Very High Very High Very High
anesthesia 4 27.20 Quite Low
ketamine 4 26.24 Quite Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrocalcinosis 48 90.88 High High
Aging 12 75.68 Quite High
Ankylosis 4 15.44 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Repression 8 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Calcification 4 5.00 Very Low Very Low Very Low
Low Back Pain 4 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 induced multiple signaling pathways in chondrocytes but that neither p38-MAPK nor PKA contributed to its stimulating effect on the Ank gene.


Regulation (effect) of Ank in chondrocytes
1) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.23
1-induced signaling pathways contributing to the regulation of Ank gene
Regulation (regulation) of Ank
2) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.05
However, intracellular pathways involved in the regulation of the Ank gene are not well documented in chondrocytes, and the contribution of ANK relative to other ePPi-regulating proteins remains unclear.
Regulation (regulation) of Ank in chondrocytes
3) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.23 Pain Relevance 0
Therefore, the identification of the signaling pathway implicated in Ank regulation and subsequent ePPi production by TGF-?
Regulation (regulation) of Ank
4) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.23 Pain Relevance 0

General Comments

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