INT224542

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.82
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ankh) plasma membrane (Ankh) molecular_function (Ankh)
cellular_component (Ankh) biological_process (Ankh)
Anatomy Link Frequency
cartilage 3
chondrocytes 1
Ankh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 8 96.48 Very High Very High Very High
Kinase C 168 82.56 Quite High
addiction 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 12 99.98 Very High Very High Very High
Osteoarthritis 8 96.48 Very High Very High Very High
Aging 12 91.56 High High
Chondrocalcinosis 48 32.24 Quite Low
Repression 8 5.00 Very Low Very Low Very Low
Calcification 4 5.00 Very Low Very Low Very Low
Ankylosis 4 5.00 Very Low Very Low Very Low
Low Back Pain 4 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 in the presence of SB203580, a selective p38-MAPK inhibitor, the increase in Ank mRNA level was not affected (Figure 4b).
Positive_regulation (increase) of Transcription (level) of Ank
1) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.07
1 increased both Ank mRNA and ANK protein levels, this induction beginning as early as 6 hours.
Positive_regulation (increased) of Transcription (levels) of ANK protein
2) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.26 Pain Relevance 0.04
Moreover, chondrocytes and cartilage extracts from patients with CPPD disease express high levels of Ank mRNA [17].
Positive_regulation (levels) of Transcription (express) of Ank in cartilage associated with disease
3) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.28 Pain Relevance 0.05
Moreover, chondrocytes and cartilage extracts from patients with CPPD disease express high levels of Ank mRNA [17].
Positive_regulation (levels) of in chondrocytes Transcription (express) of Ank in cartilage associated with disease
4) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.28 Pain Relevance 0.05

General Comments

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