INT224545

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 32
Disease Relevance 3.03
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ankh) plasma membrane (Ankh) molecular_function (Ankh)
cellular_component (Ankh) biological_process (Ankh)
Anatomy Link Frequency
chondrocytes 4
fibroblasts 1
Ankh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1344 99.48 Very High Very High Very High
Osteoarthritis 64 83.44 Quite High
addiction 32 79.20 Quite High
anesthesia 32 58.80 Quite High
ketamine 32 57.84 Quite High
spinal inflammation 32 37.44 Quite Low
cytokine 32 6.76 Low Low
Immobilon 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 96 98.24 Very High Very High Very High
Chondrocalcinosis 384 97.56 Very High Very High Very High
Leukemia 32 95.28 Very High Very High Very High
Aging 96 90.96 High High
Repression 64 87.28 High High
Ankylosis 32 86.04 High High
Osteoarthritis 64 83.44 Quite High
Cancer 32 65.72 Quite High
Cardiovascular Disease 32 65.28 Quite High
Arthropathy 32 40.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1-induced expression of Ank by Gö6976 was clearly dose-dependent and reached the control level at 10 ?
Gene_expression (expression) of Ank
1) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.31
1-induced Ank expression
Gene_expression (expression) of Ank
2) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.29
1-induced Ank expression
Gene_expression (expression) of Ank
3) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.29
1-stimulated expression of Ank.


Gene_expression (expression) of Ank
4) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.30
Induction of Ank expression by TGF-?
Gene_expression (expression) of Ank
5) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
1-induced (by 3-fold and 2-fold, respectively) Ank expression.
Gene_expression (expression) of Ank
6) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.09
1 stimulated ePPi production [15] and demonstrated that this was concomitant with the increased expression of PC-1 and Ank.
Gene_expression (expression) of Ank
7) Confidence 0.77 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.35 Pain Relevance 0.07
In contrast, transfection with Ank siRNA reduced the basal ePPi level by 33% and reduced the ePPi level by 60% in TGF-?
Gene_expression (transfection) of Ank
8) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.03
1 on Ank expression was suppressed almost completely by calphostin, a general PKC inhibitor.
Gene_expression (expression) of Ank associated with kinase c
9) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.31
1-induced expression of Ank.
Gene_expression (expression) of Ank
10) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.07 Pain Relevance 0
1-induced expression of Ank in chondrocytes, a finding consistent with data demonstrating the activation of Ras and Raf-1 by TGF-?
Gene_expression (expression) of Ank in chondrocytes
11) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
The siRNA technology was used to investigate the respective contributions of Ank and PC-1 on TGF-?
Spec (investigate) Gene_expression (contributions) of Ank
12) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
1-induced expression of Ank.
Gene_expression (expression) of Ank
13) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.06
, decreased Ank induction by 10% whereas Gö6976, a specific inhibitor of Ca2+-dependent PKCs (PKC?
Gene_expression (induction) of Ank associated with kinase c
14) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.33
1 increased both Ank mRNA and ANK protein levels, this induction beginning as early as 6 hours.
Gene_expression (mRNA) of Ank
15) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.25 Pain Relevance 0.04
However, neither the basal expression of Ank nor its induction by TGF-?
Gene_expression (expression) of Ank
16) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.13 Pain Relevance 0.03
1 increased both Ank mRNA and ANK protein levels, this induction beginning as early as 6 hours.
Gene_expression (levels) of ANK protein
17) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.25 Pain Relevance 0.04
1-induced expression of Ank in chondrocytes, thus demonstrating that it was a non-Smad signaling event.
Gene_expression (expression) of Ank in chondrocytes
18) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.27 Pain Relevance 0.39
These data demonstrated that the Smad pathway did not play a major role in the induction of the Ank gene by TGF-?
Gene_expression (gene) of Ank
19) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.22 Pain Relevance 0.04
When chondrocytes were transfected to overexpress constitutively active Ras (Figure 6a) or Raf-1 (Figure 6b), the basal expression of Ank was increased by 2-fold and 1.5-fold, respectively.
Gene_expression (expression) of Ank in chondrocytes
20) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.24

General Comments

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