INT22455

Context Info Confidence 0.21 First Reported 1990 Last Reported 2009 Negated 2 Speculated 0 Reported most in Body Documents 8 Total Number 10 Disease Relevance 10.57 Pain Relevance 0.93

cytosol (Nbr1) lysosome (Nbr1) cytoplasm (Nbr1)

Anatomy Link Frequency peritoneal fluid 1 blood 1 Colon 1 respiratory 1 Nbr1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat endometriosis 30 98.76 colic 1 95.56 anesthesia 1 90.56 abdominal pain 5 89.44 Dismenorea 79 76.52 Pain 1 70.04 imagery 28 67.12 Taxol 3 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Cancer 82 100.00 Breast Cancer 63 99.60 Disease Progression 4 99.48 Endometriosis 5 99.32 Colon Cancer 33 99.20 Uterine Fibroids 20 98.88 Ovarian Cancer 67 98.56 Cystadenocarcinoma 105 98.32 Disease 25 97.68 Endometriosis (extended) 33 97.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Epithelial cells lining central airways (trachea, bronchi, and bronchioli) and respiratory glands were specifically stained by antibodies recognizing CA125, CA19-9, and CEA.

CA125 Binding (recognizing) of in respiratory

1) Confidence 0.21 Published 1990 Journal Cancer Section Abstract Doc Link 2297641 Disease Relevance 0.26 Pain Relevance 0.09

Massive peritoneal fluid and markedly elevated serum CA125 and CA19-9 levels associated with an ovarian endometrioma.

CA125 Binding (associated) of in peritoneal fluid associated with endometriosis

2) Confidence 0.18 Published 2009 Journal J. Obstet. Gynaecol. Res. Section Title Doc Link 20149044 Disease Relevance 0.94 Pain Relevance 0.14

We did not find vaccination significantly reduced serum tumor markers CA15-3, CEA and CA125 of these breast cancer patients.

CA125 Neg (not) Binding (find) of associated with cancer and breast cancer

3) Confidence 0.05 Published 2000 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 11155821 Disease Relevance 1.21 Pain Relevance 0.07

Combination of CCR1 mRNA, MCP1, and CA125 measurements in peripheral blood as a diagnostic test for endometriosis.

CA125 Binding (Combination) of in blood associated with endometriosis

4) Confidence 0.03 Published 2008 Journal Reprod Sci Section Title Doc Link 19050323 Disease Relevance 0.54 Pain Relevance 0.33

Breast cancer cells typically stain positive for CK7, ER and are negative for CA125, CK20, and TTF1.

CA125 Binding (negative) of associated with breast cancer

5) Confidence 0.03 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 1.29 Pain Relevance 0.03

Colon adenocarcinoma stains positive for CK20 and typically negative for CK7, CA125, TTF1 and ER.

CA125 Binding (negative) of in Colon associated with colon cancer

6) Confidence 0.03 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 1.37 Pain Relevance 0.06

Both malignancies stain positive for CK7, ER, Mesothelin and CA125.

CA125 Binding (stain) of

7) Confidence 0.03 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 2.37 Pain Relevance 0

Moreover, the immunohistochemical negativity for CA125 and WT1 ruled out a possible ovarian origin and the negativity for Cytokeratin 20(CK20) and CDX2 excluded the colic one [22,23].

CA125 Neg (negativity) Binding (negativity) of associated with colic

8) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1550421 Disease Relevance 0.68 Pain Relevance 0.08

Immunohistochemically, the primary tumor displayed strong positivity for ER, PR, COX-2, CA125 and focal positivity for p53 and aromatase (Figures 2A–F).

CA125 Binding (positivity) of associated with cancer

9) Confidence 0.02 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1913924 Disease Relevance 0.90 Pain Relevance 0.07

The leiomyoma was positive for ER, PR, weakly positive for COX-2 and negative for p53 and CA125.

CA125 Binding (negative) of associated with uterine fibroids

10) Confidence 0.02 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1913924 Disease Relevance 0.87 Pain Relevance 0.06

General Comments

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