INT224563

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) mitochondrion (Raf1) plasma membrane (Raf1)
nucleus (Raf1) cytoskeleton organization (Raf1) cytoplasm (Raf1)
Anatomy Link Frequency
chondrocytes 2
Raf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 42 98.96 Very High Very High Very High
Osteoarthritis 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrocalcinosis 12 26.44 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Calcification 1 5.00 Very Low Very Low Very Low
Ankylosis 1 5.00 Very Low Very Low Very Low
Low Back Pain 1 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 increases ePPi levels, mainly by the induction of the Ank gene, which requires activation of Ras, Raf-1, ERK, and Ca2+-dependent PKC pathways in chondrocytes.



Positive_regulation (requires) of Positive_regulation (activation) of Raf-1 in chondrocytes associated with kinase c
1) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0.20

General Comments

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