INT224580

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.34
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
endoplasmic reticulum (SERPINH1) response to stress (SERPINH1) cell-cell signaling (IL18)
Anatomy Link Frequency
articular 2
IL18 (Homo sapiens)
SERPINH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 30 100.00 Very High Very High Very High
rheumatoid arthritis 87 97.38 Very High Very High Very High
Inflammation 51 95.62 Very High Very High Very High
cytokine 43 84.40 Quite High
anakinra 1 38.40 Quite Low
chemokine 12 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 13 100.00 Very High Very High Very High
Rheumatoid Arthritis 87 97.38 Very High Very High Very High
Arthritis 23 97.08 Very High Very High Very High
INFLAMMATION 53 95.62 Very High Very High Very High
Juvenile Chronic Polyarthritis 2 84.72 Quite High
Syndrome 1 80.88 Quite High
Synovitis 2 68.56 Quite High
Alzheimer's Dementia 1 48.88 Quite Low
Disease 20 28.80 Quite Low
Apoptosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pro-inflammatory role of IL-18 in arthritis (and its potential suitability as a therapeutic target in RA) is indicated by the following findings: (a) IL-18 treatment markedly aggravates experimental arthritis [59], (b) intra-articular overexpression of IL-18 induces experimental arthritis, (c) IL-18 is involved in the development of experimental streptococcal arthritis (a strongly M?
Gene_expression (overexpression) of IL-18 in articular Positive_regulation (induces) of arthritis associated with inflammation, rheumatoid arthritis, experimental arthritis and arthritis
1) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.34 Pain Relevance 0.70

General Comments

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