INT224583

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2, IL1RN) extracellular region (CSF2, IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
CSF2 (Homo sapiens)
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 3 100.00 Very High Very High Very High
Inflammation 51 98.96 Very High Very High Very High
antagonist 4 98.32 Very High Very High Very High
cytokine 43 93.08 High High
rheumatoid arthritis 87 92.04 High High
Arthritis 30 84.48 Quite High
chemokine 12 62.24 Quite High
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 53 100.00 Very High Very High Very High
Rheumatoid Arthritis 87 92.04 High High
Juvenile Chronic Polyarthritis 2 84.48 Quite High
Disease 20 78.60 Quite High
Apoptosis 7 71.24 Quite High
Experimental Arthritis 13 58.16 Quite High
Arthritis 23 14.88 Low Low
Necrosis 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
constitutively express IL-1RA, which is upregulated by pro-inflammatory mediators, including IL-1 itself or GM-CSF, and induces strong anti-inflammatory effects.
GM-CSF Positive_regulation (upregulated) of IL-1RA associated with inflammatory mediators and inflammation
1) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.30 Pain Relevance 0.88

General Comments

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