INT224608

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.34
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SERPINH1) response to stress (SERPINH1)
Anatomy Link Frequency
margin 2
SERPINH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 30 100.00 Very High Very High Very High
Inflammatory mediators 3 93.16 High High
cytokine 49 86.08 High High
Inflammation 60 80.84 Quite High
rheumatoid arthritis 87 77.76 Quite High
metalloproteinase 3 19.76 Low Low
fibrosis 3 6.24 Low Low
chemokine 15 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 23 100.00 Very High Very High Very High
Targeted Disruption 3 99.98 Very High Very High Very High
Cancer 58 98.68 Very High Very High Very High
Neuroblastoma 50 98.48 Very High Very High Very High
Dermal Scarring 48 98.32 Very High Very High Very High
Keloid Scars 6 94.20 High High
INFLAMMATION 60 92.76 High High
Adhesions 4 86.48 High High
Apoptosis 11 85.64 High High
Necrosis 8 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overexpression of SERPINH1, which showed a 5.7-fold upregulation in keloid margin in this study (P = .003), has been suggested to promote excessive collagen deposition in keloids.33 LGALS1 is a type of lectin that has been implicated in cell-cell and cell-matrix interactions and has been suggested to be involved in tumor progression, at least partly, through the induction of T-cell apoptosis.34 IGFBP7 shows a 2.8-fold upregulation in keloid margins (P = .022).
Positive_regulation (overexpression) of Gene_expression (overexpression) of SERPINH1 in margin associated with dermal scarring, cancer, apoptosis and keloid scars
1) Confidence 0.55 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 1.06 Pain Relevance 0
Previously, expression of HSP47 was reported to be upregulated after treatment with 5-aza-dC in the neuroblastoma cell line NB2-W-S and promoter region methylation was detected in neuroblastoma cell lines and 4/7 primary neuroblastoma tumours analysed (Yang et al. 2004).
Positive_regulation (upregulated) of Gene_expression (expression) of HSP47 associated with neuroblastoma and cancer
2) Confidence 0.41 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.07 Pain Relevance 0
Only the AmniSure┬« ROM test for the diagnosis of PPROM, based upon the detection of placental ?
Positive_regulation (upon) of Gene_expression (diagnosis) of PPROM
3) Confidence 0.10 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0 Pain Relevance 0
Interestingly, the transgenic expression of this form is alone sufficient to induce chronic arthritis [38]; likewise, a mutant membrane TNF-?
Positive_regulation (induce) of Gene_expression (expression) of arthritis associated with targeted disruption and arthritis
4) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.21 Pain Relevance 0.58

General Comments

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