INT224609

Context Info Confidence 0.08 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.09 Pain Relevance 0.21

extracellular space (LEFTY2) extracellular region (LEFTY2)

LEFTY2 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 87 96.92 antagonist 4 87.92 cytokine 43 34.72 Inflammation 51 29.12 chemokine 12 21.84 Arthritis 30 8.44 Inflammatory mediators 3 5.00 corticosteroid 1 5.00 methotrexate 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Cancer 6 97.88 Necrosis 6 97.64 Rheumatoid Arthritis 87 96.92 Disease 20 65.76 Autoimmune Disease 1 41.44 INFLAMMATION 53 29.12 Arthritis 23 8.44 Experimental Arthritis 13 5.00 Apoptosis 7 5.00 Adhesions 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

= transforming growth factor-beta; TIMP = tissue inhibitor of metalloprotease; TLR = Toll-like receptor; TNF = tumor necrosis factor; TNF-R1 = tumor necrosis factor receptor 1; TNF-R2 = tumor necrosis factor receptor 2.

Negative_regulation (inhibitor) of transforming growth factor-beta associated with necrosis and cancer

1) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.09 Pain Relevance 0.21

General Comments

This test has worked.