INT224615

Context Info Confidence 0.59 First Reported 2007 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 2.99 Pain Relevance 2.09

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency DA neurons 4 muscle 2 striatum 2 Pten (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 54 99.96 Dopamine 345 99.84 Catecholamine 3 98.60 midbrain 45 97.24 Dynorphin 18 94.32 tolerance 5 87.12 Arthritis 5 85.56 Inflammation 53 83.52 5HT 3 80.88 Eae 21 78.20

Disease Link Frequency Relevance Heat Cancer 62 100.00 Rheumatoid Arthritis 54 99.96 Death 34 99.12 Apoptosis 65 97.12 Autoimmune Disease 46 94.52 Lymphoproliferative Disease 4 93.84 Disease 95 92.00 Adenocarcinoma 60 91.92 Severe Combined Immunodeficiency 8 88.24 Experimental Arthritis 1 85.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mice lacking PTEN expression in DA cells showed an increase in catecholamine content in both the midbrain containing the DA cell bodies (fig. 6D) and in the terminal region in the dorsal striatum (fig. 6B).

Negative_regulation (lacking) of Gene_expression (expression) of PTEN in striatum associated with dopamine, catecholamine and midbrain

1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 1.01

Suppressing PTEN expression protects DA neurons against exposure to a neurotoxin

Negative_regulation (Suppressing) of Gene_expression (expression) of PTEN in DA neurons associated with dopamine

2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.34

Disruption of PTEN activity in DA neurons during postmitotic developmental growth

Negative_regulation (Disruption) of Gene_expression (activity) of PTEN in DA neurons associated with dopamine

3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.43 Pain Relevance 0.45

Therefore, while the increased activation of PKB in the overloaded PLN muscle of the PTEN?

Negative_regulation (overloaded) of Gene_expression (muscle) of PTEN in muscle

4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.22 Pain Relevance 0

In contrast, high levels of p-STAT3 (p = 0.01) and loss of PTEN (p = 0.01) appeared not to be associated with cancer progression.

Negative_regulation (loss) of Gene_expression (levels) of PTEN associated with cancer

5) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.66 Pain Relevance 0

In RA, lack of PTEN expression, but not mutations within the gene encoding PTEN, participate in the long-term persistence of activated RASFs in the synovial lining at sites of destruction [63].

Negative_regulation (lack) of Gene_expression (expression) of PTEN associated with rheumatoid arthritis

6) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.05 Pain Relevance 0.21

The miR-17–92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim [102].

Negative_regulation (suppressed) of Gene_expression (expression) of PTEN associated with cancer

7) Confidence 0.13 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.47 Pain Relevance 0.08

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