INT224620

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 8.35
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Anatomy Link Frequency
lung 18
myeloid progenitor cells 2
osteoclasts 2
epithelial cells 2
lacuna 2
Ctsk (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 261 99.00 Very High Very High Very High
Inflammation 130 97.12 Very High Very High Very High
metalloproteinase 25 95.68 Very High Very High Very High
Arthritis 42 87.60 High High
Tendonitis 3 85.52 High High
anesthesia 20 82.72 Quite High
rheumatoid arthritis 60 81.92 Quite High
halothane 10 33.00 Quite Low
Pain 2 26.64 Quite Low
agonist 20 26.20 Quite Low
Disease Link Frequency Relevance Heat
Hypercalcemia 16 100.00 Very High Very High Very High
Targeted Disruption 250 99.44 Very High Very High Very High
Pulmonary Fibrosis 230 99.00 Very High Very High Very High
Osteoporosis 119 97.84 Very High Very High Very High
INFLAMMATION 125 97.12 Very High Very High Very High
Fibrosis 51 95.60 Very High Very High Very High
Pressure And Volume Under Development 9 94.40 High High
Pulmonary Disease 20 93.84 High High
Injury 22 91.60 High High
Cicatrix 20 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another recent study showed increased CatK expression during osteoclastogenesis [31].
Positive_regulation (increased) of Gene_expression (expression) of CatK
1) Confidence 0.68 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.47 Pain Relevance 0.07
Hu et al [30] reported that the expression of CatK is increased during osteoclast differentiation in myeloid progenitor cells.
Positive_regulation (increased) of Gene_expression (expression) of CatK in myeloid progenitor cells
2) Confidence 0.68 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.47 Pain Relevance 0.06
Over-expression of cathepsin K reduced lung collagen deposition and improved lung function parameters in the lungs of transgenic mice, thereby providing at least partial protection against bleomycin-induced lung fibrosis.



Positive_regulation (expression) of Gene_expression (expression) of cathepsin K in lung associated with targeted disruption, fibrosis and pulmonary fibrosis
3) Confidence 0.46 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2490691 Disease Relevance 0.63 Pain Relevance 0.20
Wild-type and cathepsin K overexpressing (cathepsin K transgenic; cath K tg) mice were challenged intratracheally with bleomycin and sacrificed at 1, 2, 3 and 4 weeks post-treatment followed by determination of lung fibrosis by estimating lung collagen content, lung histopathology, leukocytic infiltrates and lung function.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of cathepsin K in lung associated with targeted disruption, fibrosis and pulmonary fibrosis
4) Confidence 0.46 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2490691 Disease Relevance 0.85 Pain Relevance 0.22
In the current study, we show that cathepsin K overexpressing mice were partially protected from bleomycin-induced pulmonary fibrosis compared to wild-type mice exhibiting a normal cathepsin K expression in their lungs, as assessed by partially reduced lung collagen contents and lack of increasing lung resistance in response to bleomycin challenge.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of cathepsin K in lungs associated with fibrosis and pulmonary fibrosis
5) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.54 Pain Relevance 0.11
Over-expression of cathepsin K reduced lung collagen deposition and improved lung function parameters in the lungs of transgenic mice, thereby providing at least partial protection against bleomycin-induced lung fibrosis.



Positive_regulation (Over) of Gene_expression (expression) of cathepsin K in lung associated with targeted disruption, fibrosis and pulmonary fibrosis
6) Confidence 0.46 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2490691 Disease Relevance 0.63 Pain Relevance 0.20
Together, this study shows that overexpression of cathepsin K does not adversely affect normal lung architecture in mice but at least partially protects against peak lung fibrotic responses and lung resistance upon bleomycin challenge.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cathepsin K in lung associated with fibrosis
7) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.61 Pain Relevance 0.13
Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis

Background

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of cathepsin K in lung associated with fibrosis and pulmonary fibrosis
8) Confidence 0.46 Published 2008 Journal Respir Res Section Title Doc Link PMC2490691 Disease Relevance 0.81 Pain Relevance 0.21
At the same time, an increased expression of cathepsin K particularly in alveolar macrophages and lung tissue homogenate but not in type II alveolar epithelial cells both under baseline conditions and in response to bleomycin was noted, suggesting that alveolar macrophages but not type II alveolar epithelial cells contributed, at least in part, to the increased collagenolytic activities in the transgenic as opposed to wild-type mice challenged with bleomycin.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of cathepsin K in epithelial cells associated with targeted disruption
9) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.30 Pain Relevance 0.04
We initially characterized cathepsin K overexpression in the lungs of transgenic mice compared to wild-type mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cathepsin K in lungs associated with targeted disruption
10) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.17 Pain Relevance 0.08
In the present study, we found that global overexpression of cathepsin K effected a partially increased extracellular matrix turnover in the lungs of mice challenged with bleomycin.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cathepsin K in lungs
11) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.40 Pain Relevance 0.07
Characterization of cathepsin K overexpression in the lungs of mice
Positive_regulation (overexpression) of Gene_expression (overexpression) of cathepsin K in lungs
12) Confidence 0.46 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.16 Pain Relevance 0.08
According to Väänänen et al [32], a high level of CatK expression secreted by osteoclasts in the lacuna is an indicator of the resorption process.
Positive_regulation (level) of Gene_expression (expression) of CatK in lacuna
13) Confidence 0.45 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.46 Pain Relevance 0.09
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Positive_regulation (increases) of Gene_expression (expression) of cathepsin K in osteoclasts associated with hypercalcemia
14) Confidence 0.13 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.09 Pain Relevance 0.28
The production of cathepsin K appears to be the main contribution of RASFs to bone degradation.
Positive_regulation (contribution) of Gene_expression (production) of cathepsin K
15) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.77 Pain Relevance 0.38

General Comments

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