INT224624

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.61
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il21) extracellular region (Il21)
Anatomy Link Frequency
platelet 1
Il21 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 76 98.88 Very High Very High Very High
cytokine 44 97.92 Very High Very High Very High
Arthritis 56 97.20 Very High Very High Very High
Inflammation 37 89.40 High High
chemokine 5 68.88 Quite High
metalloproteinase 25 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 76 98.88 Very High Very High Very High
Disease 37 98.80 Very High Very High Very High
Arthritis 58 97.20 Very High Very High Very High
INFLAMMATION 40 89.40 High High
Disease Progression 1 71.92 Quite High
Apoptosis 28 57.40 Quite High
Autoimmune Disease 1 23.44 Low Low
Hypersensitivity 3 17.12 Low Low
Pressure And Volume Under Development 15 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent publication reported that blockade of IL-21 effects with a murine IL-21 receptor Fc fusion protein attenuated disease in both mouse and rat models of arthritis [22].
IL-21 Binding (receptor) of associated with disease and arthritis
1) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.13 Pain Relevance 0.51
For example, the receptor for IL-21 was found to be expressed on RASFs, but mRNA for IL-21 was neither detectable in RA synovium nor inducible by key proinflammatory cytokines and growth factors such as IL-1, TNF, platelet-derived growth factor and TGF.
IL-21 Binding (receptor) of in platelet associated with rheumatoid arthritis and cytokine
2) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.48 Pain Relevance 0.48

General Comments

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