INT224626

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.51
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il21) extracellular region (Il21)
Anatomy Link Frequency
platelet 1
Il21 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 228 99.84 Very High Very High Very High
rheumatoid arthritis 184 99.84 Very High Very High Very High
cytokine 110 97.88 Very High Very High Very High
Inflammation 67 91.00 High High
chemokine 7 66.16 Quite High
Inflammatory response 3 19.44 Low Low
metalloproteinase 27 5.00 Very Low Very Low Very Low
Crohn's disease 10 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 24 99.96 Very High Very High Very High
Arthritis 196 99.84 Very High Very High Very High
Rheumatoid Arthritis 184 99.84 Very High Very High Very High
Disease 97 99.52 Very High Very High Very High
INFLAMMATION 64 91.00 High High
Disease Progression 1 73.52 Quite High
Apoptosis 28 54.68 Quite High
Infection 2 39.76 Quite Low
Autoimmune Disease 13 20.48 Low Low
Hypersensitivity 3 18.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent publication reported that blockade of IL-21 effects with a murine IL-21 receptor Fc fusion protein attenuated disease in both mouse and rat models of arthritis [22].
Negative_regulation (blockade) of IL-21 associated with disease and arthritis
1) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.17 Pain Relevance 0.49
In line with this, blocking IL-21 in CIA by in vivo administration of soluble IL-21R-Fc fusion protein delayed the onset and progression of arthritis [35].
Negative_regulation (blocking) of IL-21 associated with arthritis
2) Confidence 0.09 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.92 Pain Relevance 0.35
In addition, in MLR/lpr mice, a spontaneous model for SLE, blocking IL-21 attenuated disease [24].
Negative_regulation (blocking) of IL-21 associated with disease and systemic lupus erythematosus
3) Confidence 0.08 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.93 Pain Relevance 0.34
For example, the receptor for IL-21 was found to be expressed on RASFs, but mRNA for IL-21 was neither detectable in RA synovium nor inducible by key proinflammatory cytokines and growth factors such as IL-1, TNF, platelet-derived growth factor and TGF.
Neg (nor) Negative_regulation (detectable) of IL-21 in platelet associated with rheumatoid arthritis and cytokine
4) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.49 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox