INT224630

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.14
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 4 97.20 Very High Very High Very High
tolerance 36 95.12 Very High Very High Very High
cytokine 81 92.64 High High
chemokine 26 77.60 Quite High
agonist 14 76.00 Quite High
rheumatoid arthritis 59 69.84 Quite High
Inflammation 135 58.72 Quite High
Arthritis 8 23.00 Low Low
ischemia 10 10.36 Low Low
metalloproteinase 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 334 99.16 Very High Very High Very High
Metastasis 188 97.58 Very High Very High Very High
Hemorrhage 4 97.20 Very High Very High Very High
Hemorrhagic Shock 64 92.00 High High
Necrosis 5 89.92 High High
Yersinia Infection 4 88.60 High High
Brain Tumor 4 88.32 High High
Shock 26 82.72 Quite High
Systemic Lupus Erythematosus 6 81.44 Quite High
Lewis Lung Carcinoma 5 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, HSP60 activation of TLR2 mediates the expression and phosphorylation of Stat3 in tumor cells.
Positive_regulation (mediates) of Positive_regulation (activation) of TLR2 associated with cancer
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.73 Pain Relevance 0.04
Fourthly, the TLR2 activation of Stat3 is partially dependent of IL-6 and IL-10.
Spec (partially) Positive_regulation (dependent) of Positive_regulation (activation) of TLR2
2) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.66 Pain Relevance 0.03
Our studies not only demonstrate that targeting TLR2 generates metastases clearing immunity, but also reveals a signal transduction pathway in the tumor by which HSP60 liberated from B16 cells, causes a persistent activation of TLR2 to maintain the constitutive activity and function of Stat3 in these cells and determine the development of tumor immune tolerance.
Positive_regulation (causes) of Positive_regulation (activation) of TLR2 associated with cancer, tolerance and metastasis
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.97 Pain Relevance 0.05
Biglycan was recently shown to induce the NLRP3/ASC inflammasome through activation of TLR2/4 and purinergic P2X4/P2X7 receptors [87].
Positive_regulation (induce) of Positive_regulation (activation) of TLR2
4) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.08 Pain Relevance 0.04
Activation of TLR2 by LPS significantly enhanced the expression of TLR2 on these cells (Figure S1E).
Positive_regulation (enhanced) of Positive_regulation (Activation) of TLR2
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.19 Pain Relevance 0.19
We have reported an important role of PMN NADPH oxidase in mediating amplified LPS-induced TLR2 upregulation in AM?
Positive_regulation (induced) of Positive_regulation (upregulation) of TLR2
6) Confidence 0.29 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.58 Pain Relevance 0.05
The ROS derived from PMN NADPH oxidase not only play an important role in enhancing TLR2 upregulation in AM?
Positive_regulation (enhancing) of Positive_regulation (upregulation) of TLR2
7) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.32 Pain Relevance 0.03
Furthermore, TLR2 and TLR4 activation induced synthesis of IL-15 in RASFs via nuclear factor-?
Positive_regulation (induced) of Positive_regulation (activation) of TLR2
8) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.60 Pain Relevance 0.30

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