INT224635

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lgals3bp) cell adhesion (Lgals3bp) proteinaceous extracellular matrix (Lgals3bp)
Anatomy Link Frequency
joints 1
synovial cell 1
Lgals3bp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 158 99.84 Very High Very High Very High
rheumatoid arthritis 104 99.44 Very High Very High Very High
Osteoarthritis 2 97.84 Very High Very High Very High
cytokine 67 86.40 High High
methotrexate 8 37.92 Quite Low
Arthritis 10 12.16 Low Low
metalloproteinase 50 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 167 99.84 Very High Very High Very High
Rheumatoid Arthritis 104 99.44 Very High Very High Very High
Osteoarthritis 2 97.84 Very High Very High Very High
Apoptosis 56 94.76 High High
Congenital Anomalies 43 93.68 High High
Metastasis 4 92.96 High High
Cancer 15 92.36 High High
Cerebral Malaria 2 87.84 High High
Disease 41 85.20 High High
Infection 81 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, high levels of galectin-3 binding protein were associated with high levels of cartilage oligomeric matrix protein, which is a marker of synovial cell activation and joint destruction [77].
Positive_regulation (levels) of galectin-3 binding protein in synovial cell
1) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.78 Pain Relevance 0.25
Also, galectin-3 binding protein was found to be elevated in joints of RA patients as compared with patient with osteoarthritis and healthy control individuals.
Positive_regulation (elevated) of galectin-3 binding protein in joints associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.77 Pain Relevance 0.25
Counterbalancing the IFN/inflammation is the increase in the cyclophilin associated protein scavenger receptor Lgals3b [113].
Positive_regulation (increase) of Lgals3b associated with inflammation
3) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.76 Pain Relevance 0.09

General Comments

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