INT224643

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 11.10
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf10)
Anatomy Link Frequency
articular 8
cardiomyocytes 2
synovial cell 2
keratinocyte 2
Tnfsf10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 186 98.24 Very High Very High Very High
rheumatoid arthritis 403 97.96 Very High Very High Very High
chemokine 29 97.52 Very High Very High Very High
Arthritis 212 97.44 Very High Very High Very High
fortral 8 94.64 High High
agonist 8 94.04 High High
antagonist 14 87.96 High High
ischemia 2 76.48 Quite High
Inflammation 257 75.88 Quite High
Inflammatory stimuli 2 16.24 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 410 100.00 Very High Very High Very High
Cancer 165 100.00 Very High Very High Very High
Necrosis 30 100.00 Very High Very High Very High
Lymphatic System Cancer 95 98.24 Very High Very High Very High
Rheumatoid Arthritis 403 97.96 Very High Very High Very High
Myocardial Infarction 106 97.48 Very High Very High Very High
Arthritis 202 97.44 Very High Very High Very High
Thymoma 1 94.76 High High
Coronary Artery Disease 7 88.04 High High
Melanoma 126 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rimcazole did not upregulate TRAIL-R1 or TRAIL-R2 expression (data not shown), but augmented the activation of initiator caspase-8 and initiator caspase-9 upon anti-MCSP:TRAIL treatment (Additional file 3, Figure S2A and B, respectively).
Neg (not) Positive_regulation (upregulate) of Gene_expression (expression) of TRAIL
1) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.63 Pain Relevance 0.19
Rimcazole did not upregulate TRAIL-R1 or TRAIL-R2 expression (data not shown), but augmented the activation of initiator caspase-8 and initiator caspase-9 upon anti-MCSP:TRAIL treatment (Additional file 3, Figure S2A and B, respectively).
Neg (not) Positive_regulation (upregulate) of Gene_expression (expression) of TRAIL
2) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.63 Pain Relevance 0.19
In particular, at discharge (approximately 5–6 days after admission), the serum levels of TRAIL were already significantly increased, compared to the acute phase, but still significantly (p<0.01) lower with respect to normal controls (Figure 1).
Positive_regulation (increased) of Gene_expression (levels) of TRAIL
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.51 Pain Relevance 0
Interestingly, one study has reported enhanced expression of transmembrane TRAIL on the cell surface of circulating CD3+ and CD14+ cells after AMI and has documented the expression of two of the four transmembrane receptors for TRAIL, TRAIL-R1 and TRAIL-R2, in human cardiomyocytes [3].
Positive_regulation (enhanced) of Gene_expression (expression) of TRAIL in cardiomyocytes associated with myocardial infarction
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.90 Pain Relevance 0.12
Furthermore, TRAIL gene transfer may be a useful strategy to test in animal models of RA to examine the extent to which apoptosis induction in synoviocytes ameliorates arthritis severity.
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL associated with rheumatoid arthritis, apoptosis and arthritis
5) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.06 Pain Relevance 0.28
However, high levels of TRAIL-R4 decoy receptor expression correlated with TRAIL resistance.
Positive_regulation (levels) of Gene_expression (expression) of TRAIL-R4
6) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.92 Pain Relevance 0.26
Whereas Sag exposure did not induce alterations in the expression of Bcl-2, TRAIL or TNFR1, interaction of Sags with the cognate V?
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of TRAIL
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.05 Pain Relevance 0
These CpG motifs induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression [17] and increase serum levels of mouse keratinocyte-derived chemokine (KC), a functional homolog of human interleukin IL-8 [18].
Positive_regulation (induce) of Gene_expression (expression) of TRAIL in keratinocyte associated with chemokine, necrosis, cancer and apoptosis
8) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.56 Pain Relevance 0.17
Terzioglu et al. [130] employed adenoviral human TRAIL (i.e., Ad5hTRAIL) gene transfer in an attempt to overcome TRAIL-induced apoptosis resistance in primary synovial cell cultures obtained from RA patients.
Positive_regulation (transfer) of Gene_expression (transfer) of TRAIL in synovial cell associated with rheumatoid arthritis and apoptosis
9) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.93 Pain Relevance 0.27
Moreover, intra-articular over-expression of TRAIL by viral gene transfer exerted a comparable effect in a rabbit arthritis model.
Positive_regulation (expression) of Gene_expression (over) of TRAIL in articular associated with arthritis
10) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.98 Pain Relevance 0.05
Moreover, intra-articular over-expression of TRAIL by viral gene transfer exerted a comparable effect in a rabbit arthritis model.
Positive_regulation (over) of Gene_expression (over) of TRAIL in articular associated with arthritis
11) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.98 Pain Relevance 0.05
Moreover, intra-articular over-expression of TRAIL by viral gene transfer exerted a comparable effect in a rabbit arthritis model.
Positive_regulation (expression) of Gene_expression (expression) of TRAIL in articular associated with arthritis
12) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.98 Pain Relevance 0.05
Moreover, intra-articular over-expression of TRAIL by viral gene transfer exerted a comparable effect in a rabbit arthritis model.
Positive_regulation (over) of Gene_expression (expression) of TRAIL in articular associated with arthritis
13) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.98 Pain Relevance 0.05

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