INT224680

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.19 Pain Relevance 0.18

enzyme binding (Tgfb1, Pten) cytoplasm (Tgfb1, Pten) nucleus (Tgfb1, Pten) phosphatase activity (Pten) mitochondrion (Pten) intracellular (Pten)

Tgfb1 (Mus musculus) Pten (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 52 93.28 Arthritis 5 65.08 Inflammation 24 63.04 cytokine 29 5.00 metalloproteinase 25 5.00 chemokine 5 5.00 methotrexate 4 5.00 COX-2 inhibitor 2 5.00 antagonist 2 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Disease 11 99.32 Rheumatoid Arthritis 52 93.28 Apoptosis 28 91.36 Cancer 7 72.36 Severe Combined Immunodeficiency 8 67.76 Experimental Arthritis 1 65.08 INFLAMMATION 25 63.04 Adhesions 7 5.00 Hypoxia 4 5.00 Arthritis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, PTEN has been demonstrated to be downregulated by TGF-?

TGF Negative_regulation (downregulated) of PTEN

1) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.19 Pain Relevance 0.18

General Comments

This test has worked.