INT224688

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.12 Pain Relevance 0.19

enzyme binding (Pten, Akt1) cytoplasm (Pten, Akt1) nucleus (Pten, Akt1) plasma membrane (Pten, Akt1) phosphatase activity (Pten) transport (Akt1)

Pten (Mus musculus) Akt1 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 52 85.04 Arthritis 5 70.00 Inflammation 24 67.96 cytokine 29 5.00 metalloproteinase 25 5.00 chemokine 5 5.00 methotrexate 4 5.00 COX-2 inhibitor 2 5.00 antagonist 2 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Disease 11 98.96 Rheumatoid Arthritis 52 85.04 Apoptosis 28 83.12 Cancer 7 77.28 Severe Combined Immunodeficiency 8 72.68 Experimental Arthritis 1 70.00 INFLAMMATION 25 67.96 Adhesions 7 5.00 Hypoxia 4 5.00 Arthritis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, it can be speculated that the lack of the tyrosine kinase PTEN in aggressive RASFs contributes to the imbalance of tyrosine kinases and phosphatases in this disease.

PTEN Regulation (contributes) of kinases associated with disease

1) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.12 Pain Relevance 0.19

General Comments

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