INT224700

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, Angpt1) extracellular space (TNF, Angpt1) extracellular region (TNF, Angpt1)
plasma membrane (TNF, Angpt1) cell differentiation (Angpt1) intracellular (TNF)
Anatomy Link Frequency
synovium 1
TNF (Homo sapiens)
Angpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 52 100.00 Very High Very High Very High
cytokine 29 99.60 Very High Very High Very High
Arthritis 5 94.36 High High
Inflammation 24 85.84 High High
metalloproteinase 25 75.20 Quite High
antagonist 2 44.96 Quite Low
Leflunomide 1 37.16 Quite Low
chemokine 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 52 100.00 Very High Very High Very High
Arthritis 4 94.36 High High
Disease 11 92.80 High High
INFLAMMATION 25 85.84 High High
Hypoxia 4 68.20 Quite High
Severe Combined Immunodeficiency 8 63.60 Quite High
Hyperplasia 2 56.52 Quite High
Adhesions 7 42.16 Quite Low
Apoptosis 28 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This angiogenesis-inducing effect of cytokines could be shown for angiopoietin-1, which is present in RA synovium and is upregulated in RASFs by TNF-?
TNF Positive_regulation (upregulated) of angiopoietin-1 in synovium associated with rheumatoid arthritis and cytokine
1) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.63 Pain Relevance 0.34

General Comments

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