INT224726

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
endothelial cell 2
Fgf2 (Mus musculus)
Cia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 84 100.00 Very High Very High Very High
rheumatoid arthritis 46 100.00 Very High Very High Very High
cytokine 13 94.88 High High
chemokine 8 93.16 High High
Inflammation 15 14.40 Low Low
cINOD 1 5.04 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 87 100.00 Very High Very High Very High
Rheumatoid Arthritis 47 100.00 Very High Very High Very High
Disease 24 33.64 Quite Low
INFLAMMATION 17 14.40 Low Low
Cancer 6 9.12 Low Low
Necrosis 3 8.56 Low Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Immunization 5 5.00 Very Low Very Low Very Low
Erythema 4 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that long-term administration of PPI-2458 reduces chronic relapsing CIA, a model that has previously been shown to mimic human RA, and to abolish endothelial cell angiogenic responses to key mediators, namely VEGF and FGF-2.
Negative_regulation (reduces) of FGF-2 Binding (abolish) of CIA in endothelial cell associated with rheumatoid arthritis and arthritis
1) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 0.92 Pain Relevance 0.62

General Comments

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