INT224738

Context Info Confidence 0.29 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.72 Pain Relevance 0.30

plasma membrane (PTGER2) signal transducer activity (PTGER2)

Anatomy Link Frequency epithelium 2 PGE2 2 PTGER2 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 27 93.92 COX-2 inhibitor 8 86.12 Bioavailability 2 73.60 agonist 32 58.88 Inflammation 9 12.36 Osteoarthritis 19 5.00 corticosteroid 2 5.00 sSRI 2 5.00 fibrosis 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 46 100.00 Colorectal Cancer 72 99.84 Colon Cancer 2 96.72 INFLAMMATION 13 93.72 Death 4 74.20 Injury 14 50.12 Cancer 30 44.76 Osteoarthritis 19 5.00 Disease 3 5.00 Necrosis 2 5.00

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Removal of extracellular PGE2 is partially performed by a specific prostaglandin transporter, PGT, and further degradation of PGE2 is by the enzymes 15-prostaglandin-dehydrogenase, 15-PGDH, and carbonyl reductase, CBR, of which, both the activity by PGT and 15-PGDH are reduced in CRC cells, Figure 1[3,38,39].

Negative_regulation (reduced) of Protein_catabolism (degradation) of PGE2 associated with colorectal cancer

1) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.60 Pain Relevance 0

Thus, the combined effects of increased synthesis and export together with reduced elimination and degradation of extracellular PGE2 in CRC point to a maintained higher level of PGE2 in the auto-/paracrine milieu in the CRC colonic epithelium, Figure 1.

Negative_regulation (reduced) of Protein_catabolism (degradation) of PGE2 in epithelium associated with colorectal cancer

2) Confidence 0.25 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.73 Pain Relevance 0.07

Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro This study investigated the release of prostaglandin E2 (PGE2) from cartilage following an impact load in vitro and the possible chondroprotective effect of cyclooxygenase-2 (COX-2) inhibition using non-steroidal anti-inflammatory drugs (NSAIDs).

Negative_regulation (reduces) of Protein_catabolism (degradation) of PGE2 in PGE2 associated with inflammation, cinod and apoptosis

3) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2246251 Disease Relevance 0.39 Pain Relevance 0.23

General Comments

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