INT22480

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Context Info
Confidence 0.19
First Reported 1990
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.31
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SHMT2) methyltransferase activity (SHMT2)
Anatomy Link Frequency
nucleus accumbens 1
SHMT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 4 99.16 Very High Very High Very High
Opioid 9 98.80 Very High Very High Very High
Nucleus accumbens 2 97.24 Very High Very High Very High
Neuropeptide 1 94.96 High High
agonist 42 92.92 High High
Catecholamine 2 59.16 Quite High
potassium channel 16 42.80 Quite Low
corticosteroid 16 41.88 Quite Low
Central nervous system 2 5.20 Low Low
Serotonin 58 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 122 99.36 Very High Very High Very High
Cancer 67 97.28 Very High Very High Very High
Pigment Disorder 64 91.04 High High
Cervical Cancer 6 86.24 High High
Skin Cancer 20 81.00 Quite High
Disease 16 58.88 Quite High
Body Weight 2 51.84 Quite High
Nicotine Addiction 6 47.76 Quite Low
Neoplastic Processes 4 44.56 Quite Low
Lung Cancer 2 10.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of opioid-like immunoreactivity was investigated using a primary antiserum recognizing the Tyr-Gly-Gly-Phe sequence common to all known opioid peptides.
Tyr-Gly-Gly-Phe Binding (recognizing) of associated with opioid
1) Confidence 0.19 Published 1990 Journal Gynecol. Oncol. Section Abstract Doc Link 2298415 Disease Relevance 0.61 Pain Relevance 0.48
Earlier, it was found that homozygous Gly-16 was associated with a more severe asthma phenotype,[14] but this has not been supported by more recent studies.[15] Gly-16 has also been associated with nocturnal asthma[16] and in children it has been reported to be associated with decreased bronchodilator response to an inhaled ?
Gly-16 Binding (associated) of associated with asthma
2) Confidence 0.07 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.54 Pain Relevance 0.16
Earlier, it was found that homozygous Gly-16 was associated with a more severe asthma phenotype,[14] but this has not been supported by more recent studies.[15] Gly-16 has also been associated with nocturnal asthma[16] and in children it has been reported to be associated with decreased bronchodilator response to an inhaled ?
Gly-16 Binding (associated) of associated with asthma
3) Confidence 0.06 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.45 Pain Relevance 0.21
A recognized beta-endorphin cleavage product, Gly-Gln, inhibits voluntary alcohol consumption when microinjected into the nucleus accumbens (AcbSh) of P rats.
Gly-Gln Binding (recognized) of in nucleus accumbens associated with nucleus accumbens and alcohol
4) Confidence 0.01 Published 2005 Journal Brain Res. Section Abstract Doc Link 16212948 Disease Relevance 0.05 Pain Relevance 0.30
GlyCl as a target for rational modulation of bioelectric signals in regenerative medicine
GlyCl Binding (target) of
5) Confidence 0.00 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.49 Pain Relevance 0
This control has an additional advantage in that glycine binds to GlyCl at a site different than that used by ivermectin (Shan et al., 2001).
GlyCl Binding (binds) of
6) Confidence 0.00 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.17 Pain Relevance 0

General Comments

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