INT224806

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.09
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria3) plasma membrane (Gria3) protein complex (Gria3)
Gria3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 26 90.28 High High
Thalamus 26 90.24 High High
cerebral cortex 8 77.00 Quite High
Spinal cord 14 74.76 Quite High
Pain 1 59.12 Quite High
Pyramidal cell 5 35.24 Quite Low
qutenza 2 33.68 Quite Low
Hippocampus 1 30.80 Quite Low
Glutamate receptor 9 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 21 94.72 High High
Sprains And Strains 40 90.60 High High
Convulsion 10 86.00 High High
Absence Epilepsy 30 81.00 Quite High
Ataxia 10 76.40 Quite High
Pain 4 59.12 Quite High
Generalized Epilepsy 4 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In double mutant studies, we also determined that while loss of Gria3 alone does not result in SWD, its presence is nevertheless associated with the high incidence of SWD in mice homozygous for the Gria4spkw1 allele.
Negative_regulation (loss) of Gria3
1) Confidence 0.56 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.47 Pain Relevance 0.10
In contrast, null mutants for the related gene Gria3 do not have SWD, and Gria3 loss actually lowers SWD of spkw1 homozygotes.
Negative_regulation (loss) of Gria3
2) Confidence 0.41 Published 2008 Journal Human Molecular Genetics Section Abstract Doc Link PMC2405903 Disease Relevance 0.56 Pain Relevance 0.12
Approximately 10% of puncta were found to lack both GluR1- and GluR3-immunoreactivity, and these may correspond to those that express the GluR4 subunit.
Negative_regulation (lack) of GluR3-immunoreactivity
3) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0.06 Pain Relevance 0.28

General Comments

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