INT22481

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Context Info
Confidence 0.65
First Reported 1990
Last Reported 2010
Negated 0
Speculated 6
Reported most in Body
Documents 28
Total Number 34
Disease Relevance 30.26
Pain Relevance 8.50

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cell differentiation (CADM1) cell adhesion (CADM1) plasma membrane (CADM1)
Anatomy Link Frequency
macrophages 3
platelet 3
monocytes 3
plasma 2
endothelial cells 2
CADM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 19 99.54 Very High Very High Very High
diclofenac 14 99.54 Very High Very High Very High
Hippocampus 16 99.40 Very High Very High Very High
Infliximab 16 99.28 Very High Very High Very High
Arthritis 21 98.78 Very High Very High Very High
cytokine 96 98.60 Very High Very High Very High
spastic colon 84 98.60 Very High Very High Very High
Inflammation 324 98.56 Very High Very High Very High
cva 55 98.24 Very High Very High Very High
Angina 18 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 106 100.00 Very High Very High Very High
Carcinoma 98 99.80 Very High Very High Very High
Depression 19 99.54 Very High Very High Very High
Stress 83 99.40 Very High Very High Very High
Acute Coronary Syndrome 34 99.24 Very High Very High Very High
Myocardial Infarction 30 99.20 Very High Very High Very High
Breast Cancer 67 98.98 Very High Very High Very High
Arthritis 17 98.78 Very High Very High Very High
Transient Ischemic Attack 10 98.68 Very High Very High Very High
Coronary Vasospasm 7 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biopsy specimens obtained on day 5, before any clinical improvement, revealed a significant reduction of epidermal DR+CD1- antigen-presenting cells, epidermal and dermal monocytes, and keratinocyte intercellular adhesion molecule-1 expression.
Gene_expression (expression) of adhesion molecule-1 in keratinocyte associated with adhesions
1) Confidence 0.65 Published 1990 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 2298969 Disease Relevance 0.35 Pain Relevance 0.17
In the present study, we demonstrate that Akt downregulates the expression of several genes of neuronal functions, including MafK, SytI, and Syn-1, and some other genes such as Canx and Cadm1 (Table 2).
Gene_expression (expression) of Cadm1 in neuronal
2) Confidence 0.41 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.29 Pain Relevance 0
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Spec (determined) Gene_expression (expression) of adhesion molecule-1 associated with diclofenac and adhesions
3) Confidence 0.38 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.36 Pain Relevance 0.38
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Spec (determined) Gene_expression (expression) of adhesion molecule-1 associated with diclofenac and adhesions
4) Confidence 0.38 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.36 Pain Relevance 0.38
Males also expressed higher activities of genes promoting cell adhesion (cell adhesion molecule 1 and claudin 16), elastin deposition in the extracellular matrix (lysyl oxidase-like 1), mucin-type O-linked glycosylation (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6), thyroid hormone inactivation (Type III iodothyronine deiodinase), lysophospholipid hydrolysis (ectonucleotide pyrophosphatase/ phosphodiesterase 2) and neurite outgrowth and arborization (neuritin 1).
Gene_expression (expressed) of cell adhesion molecule 1 in extracellular matrix associated with adhesions
5) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.25 Pain Relevance 0
We detected a small increase in expression of ICAM1 (intercellular adhesion molecule 1) in CC (Fold-change = 1.9, p-value = 0.0081), which was also consistent with the literature [17].
Gene_expression (expression) of adhesion molecule 1 associated with carcinoma and adhesions
6) Confidence 0.24 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.17 Pain Relevance 0
Biopsy specimens obtained on day 5, before any clinical improvement, revealed a significant reduction of epidermal DR+CD1- antigen-presenting cells, epidermal and dermal monocytes, and keratinocyte intercellular adhesion molecule-1 expression.
Gene_expression (expression) of adhesion molecule-1 in monocytes associated with adhesions
7) Confidence 0.22 Published 1990 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 2298969 Disease Relevance 0.35 Pain Relevance 0.17
We have also found components of a regulatory network consisting of FOXF1, vascular cell adhesion molecule-1 (VCAM1), and hepatocyte growth factor (HGF) selectively expressed in colon and urinary tract SMCs (Figure 4D).
Gene_expression (expressed) of adhesion molecule-1 in hepatocyte associated with adhesions
8) Confidence 0.19 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.15 Pain Relevance 0
Moreover, 11a treatment attenuated expression of macrophage adhesion molecule-1 (Mac-1) on extravasated polymorphonuclear leukocytes (PMNs) which indicates that the activation was reduced.
Gene_expression (expression) of macrophage adhesion molecule-1 in polymorphonuclear leukocytes associated with adhesions
9) Confidence 0.12 Published 2009 Journal Bioorg. Med. Chem. Section Abstract Doc Link 19097798 Disease Relevance 0.88 Pain Relevance 0.40
There was also expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, as well as proinflammatory molecules such as the cytokine tumor necrosis factor-?.
Gene_expression (expression) of vascular cell adhesion molecule-1 associated with necrosis, cancer, adhesions and cytokine
10) Confidence 0.10 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.30 Pain Relevance 0.24
Circulating plasma levels of P-selectin, E-selectin, and intercellular cell adhesion molecule-1 were elevated in patients with vasospastic angina, indicating an association of endothelial damage and inflammatory reaction with coronary vasospasm.55)56) Hung et al.57) prospectively investigated the association of high-sensitivity C-reactive protein (CRP), a sensitive marker of inflammation, with coronary vasospasm and no hemodynamically significant coronary artery disease in a sample of 428 patients who underwent coronary angiography.
Spec (investigated) Gene_expression (levels) of adhesion molecule-1 in coronary artery associated with coronary artery disease, inflammation, cva, coronary vasospasm and adhesions
11) Confidence 0.10 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 1.41 Pain Relevance 0.47
It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates.
Gene_expression (overexpression) of adhesion molecule-1
12) Confidence 0.09 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18444990 Disease Relevance 0.06 Pain Relevance 0
We have previously demonstrated that intra-articular glucocorticoids decrease synovial expression of ICAM-1 (intracellular adhesion molecule-1), an adhesion molecule essential for leukocyte migration, despite minimal changes in the inflammatory phenotype of the endothelial synovial cells [15].
Gene_expression (expression) of adhesion molecule-1 in articular associated with inflammation and adhesions
13) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656252 Disease Relevance 0.62 Pain Relevance 0.23
Adherence of monocytes to the endothelial surface is facilitated by the expression of the adhesion molecules vascular cell adhesion molecule-1 (V-CAM 1) and intercellular adhesion molecule-1 (ICAM-1).
Gene_expression (expression) of vascular cell adhesion molecule-1 in monocytes associated with adhesions
14) Confidence 0.07 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.78 Pain Relevance 0.18
IL-13 is a critical cytokine in the pathogenesis of allergic asthma in a mouse model of asthma,3 and is involved in several physiological changes, such as airway eosinophilia and hyper-responsiveness.4 In humans, CD4+T cells, eosinophils, mast cells, basophils, and natural killer T cells produce IL-13, inducing IgG4 and IgE synthesis in cultured B cells.5 IL-13 mRNA and protein are increased in the sputum of asthmatics and have been correlated with an increased eosinophil count6 and airway hyper-responsiveness (AHR).7 In addition, the expression of vascular cell adhesion molecule-1 (VCAM-I) is upregulated in endothelial cells, which may contribute to eosinophil migration into airway tissues.8
Gene_expression (expression) of adhesion molecule-1 in B cells associated with asthma, occupational lung diseases, adhesions, eosinophilia and cytokine
15) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.70 Pain Relevance 0.30
Genistein treatment of human breast cancer cell lines has similarly been found to induce the expression of a number of maturation markers, including casein, lipid droplets and intercellular adhesion molecule-1 [43].
Gene_expression (expression) of adhesion molecule-1 in lipid droplets associated with breast cancer and adhesions
16) Confidence 0.05 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 1.16 Pain Relevance 0
Additionally, via enhanced expression of intercellular adhesion molecule-1, IL-6 promotes the infiltration of inflammatory cells into synovial tissue, and acting synergistically with TNF-?
Gene_expression (expression) of adhesion molecule-1 associated with inflammation and adhesions
17) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.99 Pain Relevance 0.33
Significant reduction in plasma tumor necrosis factor-alpha and keratinocyte-derived chemokine, as well as reductions in myeloperoxidase activity, intracellular adhesion molecule-1 protein expression, mRNA concentrations of proinflammatory markers, and apoptosis were observed in renal cortices from both local anesthetic groups.
Gene_expression (expression) of intracellular adhesion molecule-1 protein in keratinocyte
18) Confidence 0.03 Published 2004 Journal Anesthesiology Section Body Doc Link 15448523 Disease Relevance 0.13 Pain Relevance 0
7, while colonic biopsies were examined for endothelial expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1), in samples taken from IBS patients (60% D-IBS), ulcerative colitis patients and asymptomatic patients with a negative colonoscopy for other indications.
Spec (examined) Gene_expression (expression) of adhesion molecule-1 associated with inflammatory bowel disease, spastic colon and adhesions
19) Confidence 0.03 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879823 Disease Relevance 0.37 Pain Relevance 0.72
Surprisingly, patients with ACS and depression exhibited the highest levels of platelet factor 4, beta-thromboglobulin, and platelet/endothelial cell adhesion molecule-1 when compared with myocardial infarction or angina patients without clinical depression.
Gene_expression (levels) of adhesion molecule-1 in endothelial cell associated with acute coronary syndrome, angina, depression, myocardial infarction and adhesions
20) Confidence 0.02 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12960610 Disease Relevance 1.89 Pain Relevance 0.43

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