INT22482

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.20
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CADM1) cell adhesion (CADM1) plasma membrane (CADM1)
Anatomy Link Frequency
keratinocyte 5
articular 2
macrophages 2
monocytes 1
CADM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 14 99.98 Very High Very High Very High
Infliximab 14 99.28 Very High Very High Very High
Inflammation 18 97.16 Very High Very High Very High
Pain 3 92.88 High High
cINOD 5 91.24 High High
rheumatoid arthritis 37 84.40 Quite High
spinal inflammation 16 83.48 Quite High
psoriasis 4 75.00 Quite High
metalloproteinase 2 72.08 Quite High
dexamethasone 12 64.36 Quite High
Disease Link Frequency Relevance Heat
Adhesions 11 100.00 Very High Very High Very High
Synovitis 1 98.52 Very High Very High Very High
INFLAMMATION 22 97.16 Very High Very High Very High
Pain 3 92.88 High High
Hyperplasia 1 92.04 High High
Arthritis 7 91.20 High High
Disease 25 87.96 High High
Rheumatoid Arthritis 37 84.40 Quite High
Psoriasis 6 83.52 Quite High
Low Back Pain 19 83.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biopsy specimens obtained on day 5, before any clinical improvement, revealed a significant reduction of epidermal DR+CD1- antigen-presenting cells, epidermal and dermal monocytes, and keratinocyte intercellular adhesion molecule-1 expression.
Negative_regulation (reduction) of Gene_expression (expression) of adhesion molecule-1 in keratinocyte associated with adhesions
1) Confidence 0.49 Published 1990 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 2298969 Disease Relevance 0.35 Pain Relevance 0.17
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Negative_regulation (inhibited) of Spec (determined) Gene_expression (expression) of adhesion molecule-1 associated with diclofenac and adhesions
2) Confidence 0.21 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.36 Pain Relevance 0.38
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Negative_regulation (inhibited) of Spec (determined) Gene_expression (expression) of adhesion molecule-1 associated with diclofenac and adhesions
3) Confidence 0.21 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.37 Pain Relevance 0.38
Biopsy specimens obtained on day 5, before any clinical improvement, revealed a significant reduction of epidermal DR+CD1- antigen-presenting cells, epidermal and dermal monocytes, and keratinocyte intercellular adhesion molecule-1 expression.
Negative_regulation (reduction) of in monocytes Gene_expression (expression) of adhesion molecule-1 in keratinocyte associated with adhesions
4) Confidence 0.17 Published 1990 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 2298969 Disease Relevance 0.35 Pain Relevance 0.17
It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates.
Negative_regulation (inhibition) of Gene_expression (overexpression) of adhesion molecule-1
5) Confidence 0.05 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18444990 Disease Relevance 0.07 Pain Relevance 0
We have previously demonstrated that intra-articular glucocorticoids decrease synovial expression of ICAM-1 (intracellular adhesion molecule-1), an adhesion molecule essential for leukocyte migration, despite minimal changes in the inflammatory phenotype of the endothelial synovial cells [15].
Negative_regulation (decrease) of Gene_expression (expression) of adhesion molecule-1 in articular associated with inflammation and adhesions
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656252 Disease Relevance 0.62 Pain Relevance 0.23
Significant reduction in plasma tumor necrosis factor-alpha and keratinocyte-derived chemokine, as well as reductions in myeloperoxidase activity, intracellular adhesion molecule-1 protein expression, mRNA concentrations of proinflammatory markers, and apoptosis were observed in renal cortices from both local anesthetic groups.
Negative_regulation (reductions) of Gene_expression (expression) of intracellular adhesion molecule-1 protein in keratinocyte
7) Confidence 0.02 Published 2004 Journal Anesthesiology Section Body Doc Link 15448523 Disease Relevance 0.13 Pain Relevance 0
As well as a significant reduction in the number of macrophages and polymorphonuclear cells in the sublining layer and an impaired expression of vascular cell adhesion molecule-1, suggesting that infliximab acts on synovitis in SpA by reducing the influx of inflammatory cells, there was a decrease in the hypervascularity typical of SpA and a reduction of the synovial lining hyperplasia, indicating that infliximab also modulates the structural synovial characteristics of the disease.
Negative_regulation (impaired) of Gene_expression (expression) of adhesion molecule-1 in macrophages associated with inflammation, infliximab, synovitis, disease, hyperplasia and adhesions
8) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174966 Disease Relevance 0.95 Pain Relevance 0.47

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