INT22485

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.49
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
neurons 4
plasma 2
PVH 2
medial 2
PVN 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 5 100.00 Very High Very High Very High
Enkephalin 8 99.80 Very High Very High Very High
Morphine 4 99.72 Very High Very High Very High
Pain 2 99.58 Very High Very High Very High
Action potential 6 99.56 Very High Very High Very High
isoflurane 4 99.48 Very High Very High Very High
antidepressant 8 99.40 Very High Very High Very High
dexamethasone 2 99.16 Very High Very High Very High
tetrodotoxin 5 99.04 Very High Very High Very High
antagonist 1 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 45 100.00 Very High Very High Very High
Urological Neuroanatomy 7 100.00 Very High Very High Very High
INFLAMMATION 8 97.48 Very High Very High Very High
Adhesions 5 94.56 High High
Bordatella Infection 2 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both inhaled isoflurane and intravenous propofol inhibited nitrous-oxide-induced activation of CRF neurons, suggesting that these general anesthetics may inhibit one of the analgesic mechanisms of nitrous oxide.
Negative_regulation (inhibited) of Positive_regulation (activation) of CRF in neurons associated with analgesic and isoflurane
1) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.56
General anesthetics inhibit the nitrous-oxide-induced activation of corticotropin releasing factor containing neurons in rats.
Negative_regulation (inhibit) of Positive_regulation (activation) of corticotropin releasing factor in neurons
2) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.49
Acute stress-induced increases in thalamic CRH mRNA are blocked by repeated stress exposure.
Negative_regulation (blocked) of Positive_regulation (increases) of CRH associated with stress and pain
3) Confidence 0.59 Published 2001 Journal Brain Res. Section Title Doc Link 11578616 Disease Relevance 0.77 Pain Relevance 0.27
Central to this suppression of stress responsiveness is reduced activation of the pPVN CRF neurones.
Negative_regulation (reduced) of Positive_regulation (activation) of CRF associated with stress
4) Confidence 0.47 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18601699 Disease Relevance 0.30 Pain Relevance 0.15
Substitution of the stable GTP analog guanosine 5'-O-(3'-thiotriphosphate) for GTP allows the CRH stimulation, but abolishes the CCh enhancement of both basal and CRH-stimulated enzyme activities.
Negative_regulation (abolishes) of Positive_regulation (enhancement) of CRH-stimulated
5) Confidence 0.42 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8245971 Disease Relevance 0.17 Pain Relevance 0.49
In this study, chronic morphine was shown to suppress IL-1beta-induction of corticotropin releasing factor (CRF) mRNA and plasma corticosterone levels.
Negative_regulation (suppress) of Positive_regulation (induction) of corticotropin releasing factor in plasma associated with morphine
6) Confidence 0.39 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11498262 Disease Relevance 0.89 Pain Relevance 0.65
Corticosteroid replacement studies in ADX rats indicated that lower doses of dexamethasone attenuated, and higher doses essentially abolished, the expected enhancement of both CRF and vasopressin immunoreactivity after ADX.
Negative_regulation (abolished) of Positive_regulation (enhancement) of CRF associated with corticosteroid and dexamethasone
7) Confidence 0.39 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3553442 Disease Relevance 0 Pain Relevance 0.34
Stimulation of CRH neurones in the paraventricular nucleus also activates gamma-aminobenzoic acid and opioid neurones in the medial preoptic area and reduces GnRH cell recruitment, thereby decreasing GnRH pulse frequency.
Negative_regulation (reduces) of Positive_regulation (Stimulation) of CRH in medial associated with urological neuroanatomy and opioid
8) Confidence 0.38 Published 2003 Journal Reproduction Section Abstract Doc Link 12578529 Disease Relevance 0.99 Pain Relevance 0.57
Tetrodotoxin, administered to the PVH via osmotic minipump, blocked the stress-induced rise in CRF and AVP mRNAs, but had no significant effect on basal levels of these transcripts.
Negative_regulation (blocked) of Positive_regulation (rise) of CRF in PVH associated with stress and tetrodotoxin
9) Confidence 0.31 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8401558 Disease Relevance 0.32 Pain Relevance 0.25
Inhibition of P-type Ca2+ channels with omega-agatoxin-IVA decreased action potential firing frequency and reduced the CRH-induced increase in cytosolic Ca2+.
Negative_regulation (reduced) of Positive_regulation (increase) of CRH-induced associated with action potential
10) Confidence 0.28 Published 1996 Journal Endocrinology Section Abstract Doc Link 8641175 Disease Relevance 0 Pain Relevance 0.40
Lactation inhibits stress-mediated secretion of corticosterone and oxytocin and hypothalamic accumulation of corticotropin-releasing factor and enkephalin messenger ribonucleic acids.
Negative_regulation (inhibits) of Positive_regulation (accumulation) of corticotropin-releasing factor associated with stress and enkephalin
11) Confidence 0.21 Published 1989 Journal Endocrinology Section Title Doc Link 2785027 Disease Relevance 0.35 Pain Relevance 0.43
CRF mRNA accumulation in the PVN during exposure to chronic variable stress was attenuated by concurrent antidepressant administration.
Negative_regulation (attenuated) of Positive_regulation (accumulation) of CRF in PVN associated with stress and antidepressant
12) Confidence 0.21 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861819 Disease Relevance 0.50 Pain Relevance 0.49
The stimulatory effect of CRF on prolactin secretion was reversed by i.v. administration of the opioid antagonist naloxone, suggesting that endogenous opioid peptides mediate the central effect of CRF on the release of prolactin, but not cortisol.
Negative_regulation (reversed) of Positive_regulation (effect) of CRF associated with antagonist, endogenous opioid, narcan and opioid
13) Confidence 0.04 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2299271 Disease Relevance 0.20 Pain Relevance 0.36

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