INT224882

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.77
Pain Relevance 5.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nrn1)
Anatomy Link Frequency
dentate gyrus 3
brain 1
prefrontal 1
hippocampus 1
Nrn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 272 100.00 Very High Very High Very High
Hippocampus 136 99.82 Very High Very High Very High
fluoxetine 264 99.12 Very High Very High Very High
antidepressant 176 97.80 Very High Very High Very High
depression 24 81.16 Quite High
sSRI 16 75.08 Quite High
Serotonin 8 55.92 Quite High
Pain 8 5.00 Very Low Very Low Very Low
monoamine 8 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 112 100.00 Very High Very High Very High
Affective Disorder 8 88.28 High High
Cognitive Disorder 8 87.00 High High
Amnesia 8 86.20 High High
Depression 24 81.16 Quite High
Stress 32 80.40 Quite High
Urological Neuroanatomy 24 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Convulsion 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the dentate gyrus, only neuritin and TIEG1 were upregulated after three weeks of fluoxetine treatment.
Positive_regulation (upregulated) of neuritin in dentate gyrus associated with fluoxetine
1) Confidence 0.12 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.17 Pain Relevance 0.70
In the prefrontal cortex, neuritin, Narp, TIEG1, Carp, and Arl4d were all strongly upregulated.
Positive_regulation (upregulated) of neuritin in prefrontal
2) Confidence 0.12 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.17 Pain Relevance 0.68
In the dentate gyrus (Figure 1(c)), neuritin and TIEG1 were significantly upregulated 2-fold in the chronic fluoxetine group.
Positive_regulation (upregulated) of neuritin in dentate gyrus associated with fluoxetine
3) Confidence 0.12 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.28 Pain Relevance 0.96
In the hippocampus proper, neuritin, Narp, TIEG1, and Arc were upregulated.
Positive_regulation (upregulated) of neuritin in hippocampus associated with aids-related complex and hippocampus
4) Confidence 0.12 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.17 Pain Relevance 0.70
In the dentate gyrus, only neuritin and TIEG1 were upregulated after three weeks of fluoxetine treatment.
Positive_regulation (upregulated) of neuritin in dentate gyrus associated with fluoxetine
5) Confidence 0.09 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.17 Pain Relevance 0.70
Here, we demonstrate brain region-specific upregulation of BDNF-LTP associated genes (neuritin, Narp, TIEG1 Arl4d, Carp, and Arc) after chronic, but not acute, fluoxetine administration.
Positive_regulation (upregulation) of neuritin in brain associated with aids-related complex, long-term potentiation and fluoxetine
6) Confidence 0.08 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.10 Pain Relevance 0.33
Neuritin, Carp, and Arl4d were significantly elevated more than 2-fold in response to chronic fluoxetine treatment.
Positive_regulation (elevated) of Neuritin associated with fluoxetine
7) Confidence 0.08 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.34 Pain Relevance 0.92
Recently, we identified five genes (neuritin, Narp, TIEG1, Carp, and Arl4d) that are coupregulated with Arc during BDNF-LTP.
Positive_regulation (coupregulated) of neuritin associated with aids-related complex
8) Confidence 0.08 Published 2007 Journal Neural Plasticity Section Abstract Doc Link PMC2248427 Disease Relevance 0.36 Pain Relevance 0.42

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