INT22491

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 4.51
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) extracellular region (Atrn)
plasma membrane (Atrn) molecular_function (Atrn) cytoplasm (Atrn)
Anatomy Link Frequency
plasma 3
neuronal 2
myofibrils 1
livers 1
NG108-15 1
Atrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 20 100.00 Very High Very High Very High
Clonidine 14 100.00 Very High Very High Very High
sodium channel 29 99.50 Very High Very High Very High
noradrenaline 17 99.44 Very High Very High Very High
opiate 6 99.02 Very High Very High Very High
aspirin 7 98.84 Very High Very High Very High
Potency 5 98.64 Very High Very High Very High
Serotonin 3 98.60 Very High Very High Very High
local anesthetic 9 98.40 Very High Very High Very High
ischemia 10 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 9 97.44 Very High Very High Very High
Poisoning 4 95.76 Very High Very High Very High
Pain 25 94.44 High High
Cirrhosis 3 93.64 High High
Nociception 8 92.92 High High
Fatty Liver 10 92.88 High High
Body Weight 6 92.52 High High
Cancer 9 86.64 High High
Necrosis 6 85.20 High High
Impaired Glucose Tolerance 4 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These pharmaceuticals are thought to affect the biologic system through interaction with membrane receptors.
membrane Binding (interaction) of
1) Confidence 0.30 Published 1996 Journal Cancer Lett. Section Abstract Doc Link 8603383 Disease Relevance 0.66 Pain Relevance 0.23
Two theories of the molecular mechanism of volatile anaesthetic action suggest either that anaesthetics cause a generalized perturbation of neuronal membrane structure, probably through a nonspecific interaction with membrane lipids, or that anaesthetics bind to sets of sites of appropriate molecular dimension on membrane proteins.
membrane Binding (interaction) of in neuronal
2) Confidence 0.30 Published 1987 Journal Nature Section Abstract Doc Link 3600792 Disease Relevance 0 Pain Relevance 0.14
The ability of a VAMP-specific antibody to alter binding between microsome- and plasma membrane-associated membrane proteins was examined.
membrane Binding (binding) of in plasma
3) Confidence 0.19 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10090212 Disease Relevance 0.17 Pain Relevance 0.18
Furthermore, our study shows that, in contrast to control livers, the microsome-plasma membrane binding in pancreatitic livers is VAMP-independent, which suggests an absence of VAMP participation in membrane-microsome binding.
membrane Binding (binding) of in plasma
4) Confidence 0.14 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10090212 Disease Relevance 0.15 Pain Relevance 0.19
In pancreatitic livers, a significant loss in microsome-plasma membrane binding is observed.
membrane Binding (binding) of in livers
5) Confidence 0.14 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10090212 Disease Relevance 0.16 Pain Relevance 0.19
The mechanism seemed to be different to the anesthetic action and it is supposed that it is a direct hydrophobic interaction with membrane proteins.
membrane Binding (interaction) of
6) Confidence 0.14 Published 1980 Journal Mech. Ageing Dev. Section Abstract Doc Link 7206808 Disease Relevance 0 Pain Relevance 0.55
The ability of a VAMP-specific antibody to alter binding between microsome- and plasma membrane-associated membrane proteins was examined.
membrane Binding (binding) of in plasma
7) Confidence 0.14 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10090212 Disease Relevance 0.17 Pain Relevance 0.19
On rat brain membrane homogenates and NG108-15 hybrid cells, UV irradiation of the receptor-ligand complex results in the irreversible binding to membrane proteins of 14% of the bound radioactivity Gel electrophoresis of [125I]azido-DTLET-labeled proteins followed by autoradiography shows a different pattern in rat brain and NG108-15 cells.
membrane Binding (binding) of in NG108-15
8) Confidence 0.13 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2845246 Disease Relevance 0 Pain Relevance 0.22
Six of these antibodies showed specific binding to immunoblot transfers of T-tubular membrane proteins.
membrane Binding (binding) of
9) Confidence 0.13 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2581954 Disease Relevance 0 Pain Relevance 0.28
LY141865 and LY156258 (but not the dextrorotatory isomer) inhibited the binding of tritiated apomorphine and spiperone to striatal membrane receptors, but were not as potent as pergolide, they also had less effect, or no effect, on the binding of other tritiated ligands (dopamine, WB4101, clonidine, dihydroalprenolol, pyrilamine or quinuclidinyl benzilate) to their membrane receptors.
membrane Binding (binding) of associated with dopamine and clonidine
10) Confidence 0.05 Published 1983 Journal J. Neural Transm. Section Abstract Doc Link 6655467 Disease Relevance 0 Pain Relevance 0.59
Immunoprecipitation experiments showed that authentic clonidine-displacing substance, that which displaces tritiated p-aminoclonidine binding to membrane receptors, is recognized by anti-p-aminoclonidine antibodies.
membrane Binding (binding) of associated with clonidine
11) Confidence 0.04 Published 1989 Journal Hypertension Section Abstract Doc Link 2925235 Disease Relevance 0 Pain Relevance 0.65
LY141865 and LY156258 (but not the dextrorotatory isomer) inhibited the binding of tritiated apomorphine and spiperone to striatal membrane receptors, but were not as potent as pergolide, they also had less effect, or no effect, on the binding of other tritiated ligands (dopamine, WB4101, clonidine, dihydroalprenolol, pyrilamine or quinuclidinyl benzilate) to their membrane receptors.
membrane Binding (binding) of associated with dopamine and clonidine
12) Confidence 0.04 Published 1983 Journal J. Neural Transm. Section Abstract Doc Link 6655467 Disease Relevance 0 Pain Relevance 0.57
The latter finding suggests an interaction of propranolol with the neuronal membrane transport of noradrenaline.
membrane Binding (interaction) of in neuronal associated with noradrenaline
13) Confidence 0.03 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2314483 Disease Relevance 0.72 Pain Relevance 1.01
It is suggested that the membrane form of the puromycin-sensitive aminopeptidase is identical to the soluble enzyme and that it associates with the membrane by interactions with other integral membrane proteins.
membrane Binding (interactions) of
14) Confidence 0.01 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2299352 Disease Relevance 0 Pain Relevance 0.07
Unlike tityustoxin, beta-bungarotoxin also induced release of choline and cytoplasmic lactate dehydrogenase from synaptosomes, with similar potency, suggesting that it causes some membrane disruption, following its binding to the membrane.
membrane Binding (binding) of associated with potency
15) Confidence 0.01 Published 1980 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7353009 Disease Relevance 0 Pain Relevance 0.18
After hybridization of splenocytes with myeloma cells, hybridoma lines secreting antibodies against serotonin, dopamine and opiate receptors were detected by inhibition of ligand binding to brain membrane preparations.
membrane Binding (binding) of in brain associated with dopamine, opiate and serotonin
16) Confidence 0.01 Published 1989 Journal FEBS Lett. Section Abstract Doc Link 2537236 Disease Relevance 0 Pain Relevance 0.73
CCl3, CCl3O2), which then bind covalently to membrane proteins, finally causing lipid peroxidation [1–4].
membrane Binding (bind) of
17) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2933434 Disease Relevance 0.44 Pain Relevance 0.05
Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate.
membrane Binding (interaction) of
18) Confidence 0.01 Published 2007 Journal J. Neurochem. Section Title Doc Link 17074062 Disease Relevance 0 Pain Relevance 0.09
Aspirin and nimesulide exhibited an increase in the brush border membrane (BBM) bound enzyme activities like sucrase, lactase, maltase and alkaline phosphatase in the small intestine while celecoxib showed decrease in lactase, maltase and alkaline phosphatase.
membrane Binding (bound) of in small intestine associated with aspirin
19) Confidence 0.00 Published 2006 Journal Nutr Hosp Section Abstract Doc Link 17147060 Disease Relevance 0.07 Pain Relevance 0.28
After activation of Ang II type 1 (AT1) receptors, the cytoplasmic subunits bind to the membrane subunits and activate the enzyme, resulting in the intracellular production of O2?
membrane Binding (bind) of
20) Confidence 0.00 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.75 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox