INT224947

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.48
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Ghrl (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 73 100.00 Very High Very High Very High
antagonist 74 99.24 Very High Very High Very High
Ventral tegmentum 68 99.20 Very High Very High Very High
opioid receptor 8 98.60 Very High Very High Very High
nMDA receptor antagonist 3 98.20 Very High Very High Very High
Endocannabinoid 35 97.20 Very High Very High Very High
Opioid 8 90.20 High High
Glutamate 8 83.52 Quite High
vagus nerve 2 78.20 Quite High
Somatostatin 6 51.84 Quite High
Disease Link Frequency Relevance Heat
Syndrome 88 91.04 High High
Hyperphagia 27 86.32 High High
Impaired Glucose Tolerance 21 82.64 Quite High
Insulin Resistance 18 58.00 Quite High
Targeted Disruption 64 53.60 Quite High
Appetite Loss 13 49.24 Quite Low
Anxiety Disorder 15 24.32 Low Low
Muscle Hypotonia 8 15.12 Low Low
Obesity 74 14.24 Low Low
Body Weight 27 11.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, ghrelin-induced locomotor stimulation as well as accumbal dopamine release were suppressed by VTA administration of an NMDA receptor antagonist (AP5).
Positive_regulation (induced) of Localization (release) of ghrelin associated with ventral tegmentum, nmda receptor antagonist, dopamine and antagonist
1) Confidence 0.34 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 1.05
Central administration of 1 µg ghrelin significantly increased the 2 h food intake in wild-type (WT) animals (ghrelin vs. control in WT mice: 1.02±0.08 g vs. 0.62±0.15 g Kruskal-Wallis test: n?
Positive_regulation (increased) of Localization (administration) of ghrelin
2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.05 Pain Relevance 0.23
All the more hepatic vagotomy or coinfusion with atropine methyl bromide (a muscarinic antagonist) diminished the inhibitory effect of ghrelin on glucose-stimulated insulin secretion [70].
Positive_regulation (stimulated) of Localization (secretion) of ghrelin associated with antagonist
3) Confidence 0.25 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.14 Pain Relevance 0.11
We, therefore, asked whether the deletion of the Snord116 cluster in mice causes abnormal secretion of ghrelin as well.
Spec (whether) Positive_regulation (causes) of Localization (secretion) of ghrelin
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.29 Pain Relevance 0

General Comments

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