INT224947

Context Info Confidence 0.34 First Reported 2008 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.48 Pain Relevance 1.40

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)

Ghrl (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 73 100.00 antagonist 74 99.24 Ventral tegmentum 68 99.20 opioid receptor 8 98.60 nMDA receptor antagonist 3 98.20 Endocannabinoid 35 97.20 Opioid 8 90.20 Glutamate 8 83.52 vagus nerve 2 78.20 Somatostatin 6 51.84

Disease Link Frequency Relevance Heat Syndrome 88 91.04 Hyperphagia 27 86.32 Impaired Glucose Tolerance 21 82.64 Insulin Resistance 18 58.00 Targeted Disruption 64 53.60 Appetite Loss 13 49.24 Anxiety Disorder 15 24.32 Muscle Hypotonia 8 15.12 Obesity 74 14.24 Body Weight 27 11.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, ghrelin-induced locomotor stimulation as well as accumbal dopamine release were suppressed by VTA administration of an NMDA receptor antagonist (AP5).

Positive_regulation (induced) of Localization (release) of ghrelin associated with ventral tegmentum, nmda receptor antagonist, dopamine and antagonist

1) Confidence 0.34 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 1.05

Central administration of 1 µg ghrelin significantly increased the 2 h food intake in wild-type (WT) animals (ghrelin vs. control in WT mice: 1.02±0.08 g vs. 0.62±0.15 g Kruskal-Wallis test: n?

Positive_regulation (increased) of Localization (administration) of ghrelin

2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.05 Pain Relevance 0.23

All the more hepatic vagotomy or coinfusion with atropine methyl bromide (a muscarinic antagonist) diminished the inhibitory effect of ghrelin on glucose-stimulated insulin secretion [70].

Positive_regulation (stimulated) of Localization (secretion) of ghrelin associated with antagonist

3) Confidence 0.25 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.14 Pain Relevance 0.11

We, therefore, asked whether the deletion of the Snord116 cluster in mice causes abnormal secretion of ghrelin as well.

Spec (whether) Positive_regulation (causes) of Localization (secretion) of ghrelin

4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.29 Pain Relevance 0

General Comments

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