INT224958

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.37
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 7
brains 2
pituitary gland 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 72 99.12 Very High Very High Very High
antagonist 11 86.24 High High
agonist 16 79.24 Quite High
Dopamine 16 78.88 Quite High
Pyramidal cell 2 70.76 Quite High
Calcium channel 2 44.84 Quite Low
Bile 3 33.32 Quite Low
withdrawal 2 20.88 Low Low
Neurotransmitter 5 15.04 Low Low
Central nervous system 14 12.24 Low Low
Disease Link Frequency Relevance Heat
Disease 114 99.84 Very High Very High Very High
Cancer 37 97.48 Very High Very High Very High
Adenoma 23 97.16 Very High Very High Very High
Syndrome 180 95.80 Very High Very High Very High
Congenital Anomalies 16 85.92 High High
Acromegaly 63 82.24 Quite High
Pituitary Cancer 5 75.72 Quite High
Targeted Disruption 20 71.88 Quite High
Toxicity 2 69.28 Quite High
Growth Problems 8 64.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To obtain a reliable assessment, we evaluated GH activity by measuring the mRNA and protein levels of IGF-I (insulin-like growth factor 1) and documented reduced Igf1 mRNA levels in liver, as well as reduced IGF1 protein levels in the serum, at 4 and 8 weeks of age.
Negative_regulation (reduced) of Transcription (levels) of Igf1 in liver
1) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.13 Pain Relevance 0
Although the most important effect of somatostatin analogs is the inhibition of GH secretion by the adenoma leading to a subsequent decrease in circulating liver-derived IGF-I, part of the peripheral effects of these analogs is caused by the direct inhibition of IGF-I gene transcription after binding to the somatostatin receptor (Serri et al 1992; Murray et al 2004).
Negative_regulation (inhibition) of Transcription (transcription) of IGF-I gene in liver associated with adenoma and somatostatin
2) Confidence 0.55 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.36 Pain Relevance 0.29
Since we observed a reduction in liver Igf1 mRNA expression and in circulating levels of IGF1 protein, indicative of GH deficiency, and since most individuals with PWS are GH deficient, we studied the structure and development of the pituitary gland to determine whether the GH deficiency is caused by a structural pituitary defect or a reduction in the number of GH producing cells in the anterior pituitary.
Negative_regulation (reduction) of in liver Transcription (expression) of Igf1 in pituitary gland associated with syndrome
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.29 Pain Relevance 0
Transcription of the genes for insulin and IGF1 receptors is reduced in AD brains compared with controls [80, 81].
Negative_regulation (reduced) of Transcription (Transcription) of IGF1 in brains associated with disease
4) Confidence 0.29 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.41 Pain Relevance 0.04
Although the most important effect of somatostatin analogs is the inhibition of tumor-derived GH and the subsequent fall in circulating liver-derived IGF-I, part of the peripheral effects are caused by a direct inhibition of IGF-I gene transcription via activation after binding to the somatostatin receptor (Serri et al 1992; Le Roith et al 2001; Murray et al 2004).
Negative_regulation (inhibition) of Transcription (transcription) of IGF-I gene in liver associated with cancer and somatostatin
5) Confidence 0.27 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox