INT224959

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.09
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghsr) plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
plasma 2
hypothalamus 2
neurons 2
brain 2
adipose tissue 2
Ghsr (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 62 94.44 High High
Kinase C 12 89.56 High High
antagonist 92 75.24 Quite High
agonist 28 65.16 Quite High
Action potential 48 62.24 Quite High
GABAergic 18 43.52 Quite Low
Opioid 4 39.40 Quite Low
Calcium channel 22 25.32 Quite Low
tolerance 79 22.08 Low Low
TRP channel 2 21.24 Low Low
Disease Link Frequency Relevance Heat
Obesity 223 99.64 Very High Very High Very High
Anorexia 1 96.00 Very High Very High Very High
Syndrome 92 86.80 High High
Congenital Anomalies 9 81.84 Quite High
Hyperphagia 28 76.16 Quite High
Hyperinsulinism 41 74.80 Quite High
Targeted Disruption 237 59.60 Quite High
Acromegaly 27 50.00 Quite Low
Appetite Loss 23 41.36 Quite Low
Eating Disorder 10 40.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Much later in life, aged individuals retain ghrelin-induced GH secretion as well as GHSR expression in the brain [4], [36].
Positive_regulation (induced) of Gene_expression (expression) of GHSR in brain
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.10
GHSR1b mRNA is as widely expressed as ghrelin, whereas GHSR1a gene expression is concentrated in the hypothalamus-pituitary unit, although it is also distributed in other central and peripheral tissues [15].
Positive_regulation (concentrated) of Gene_expression (expression) of GHSR1a in hypothalamus
2) Confidence 0.41 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0
Furthermore, GHSR blockade increased plasma insulin concentrations in gastrectomized and normal rats to a similar extent [91].
Positive_regulation (increased) of Gene_expression (blockade) of GHSR in plasma
3) Confidence 0.41 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0.03
cells, was indistinguishable from that of nontransgenic littermates, indicating that insulin secretion was not affected by overexpression of ghrelin transgene in vitro, although it was affected in vivo [39].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ghrelin transgene
4) Confidence 0.41 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.08 Pain Relevance 0
Peripheral ghrelin or GHS induce rapid c-fos expression in GHRH neurons [16], [17], [58].
Positive_regulation (Peripheral) of Gene_expression (Peripheral) of GHS in neurons
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.09
Patel et al. examined the expression of GHSR1a in discrete adipose tissue depots and while GHSR1a expression was detected in the epididymal and pericardial deposits, it was not found in the perirenal, subcutaneous, and omental deposits.
Positive_regulation (detected) of Gene_expression (expression) of GHSR1a in adipose tissue associated with obesity
6) Confidence 0.38 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.61 Pain Relevance 0.11
Future work crossing Snord116del mice with ghrelin-null mice and mice lacking the ghrelin receptor (also called growth hormone secretagogue receptor, GHS-R, GeneID: 208188) may define the role of ghrelin in the phenotype of Snord116del mice.


Positive_regulation (called) of Neg (lacking) Gene_expression (lacking) of ghrelin receptor
7) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.40 Pain Relevance 0.09
The physiological role of the GH-stimulatory hormone ghrelin, the native substrate for the GH- releasing peptide (GHRP) receptor, is not fully elucidated, but large GH responses are induced by GHRP or ghrelin infusion and this hormone acts synergistically with GHRH (Kojima et al 1999).
Positive_regulation (induced) of Gene_expression (infusion) of GHRP
8) Confidence 0.12 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox