INT224970

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ube3a) nucleus (Ube3a) ligase activity (Ube3a)
Anatomy Link Frequency
brain 1
Ube3a (Mus musculus)
Pain Link Frequency Relevance Heat
Electroencephalography 28 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
cerebral cortex 12 5.00 Very Low Very Low Very Low
Neurobehavioral 8 5.00 Very Low Very Low Very Low
Eae 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 11 85.68 High High
Angelman Syndrome 110 79.44 Quite High
Syndrome 94 72.56 Quite High
Hyperphagia 24 50.00 Quite Low
Convulsion 24 48.56 Quite Low
Targeted Disruption 15 29.84 Quite Low
Weight Gain 1 16.72 Low Low
Anxiety Disorder 55 5.00 Very Low Very Low Very Low
Obesity 24 5.00 Very Low Very Low Very Low
Autism 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Gabrb3 targeted cells were expanded and used subsequently for targeting of the Ube3a gene.
Regulation (targeting) of Ube3a
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.09 Pain Relevance 0
To place the loxP site at the Ube3a locus, a replacement-type targeting vector of Ube3a-pL13 was used to replace exon 2 of Ube3a with a cassette containing a loxP site, a neomycin selectable marker, and a 5?
Regulation (targeting) of Ube3a
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.16 Pain Relevance 0
Although Ube3a is expressed exclusively from the maternal allele in brain and, therefore, should not be affected by the Snord116 deletion on the paternal chromosome, a reduction of the paternal-specific antisense transcript Ube3aAS could potentially affect silencing of the paternal Ube3a allele and, thus, change its transcript level.
Neg (not) Regulation (affected) of Ube3a in brain
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.07 Pain Relevance 0

General Comments

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