INT224979

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.18
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ube3a) nucleus (Ube3a) ligase activity (Ube3a)
Anatomy Link Frequency
brain 2
Ube3a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 4 96.36 Very High Very High Very High
Electroencephalography 56 91.40 High High
Hippocampus 28 39.68 Quite Low
Neurobehavioral 10 25.00 Low Low
cerebral cortex 24 5.00 Very Low Very Low Very Low
Eae 14 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
GABA receptor 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Angelman Syndrome 220 98.84 Very High Very High Very High
Anxiety Disorder 95 94.28 High High
Convulsion 48 91.88 High High
Epilepsy 20 89.28 High High
Congenital Anomalies 19 88.76 High High
Uniparental Disomy 33 78.00 Quite High
Chromosome Deletion 4 69.16 Quite High
Syndrome 100 66.20 Quite High
Hyperphagia 24 50.00 Quite Low
Cleft Palate 28 46.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the Ube3a and Gabrb3 genes were disrupted as shown in Figure 1D and confirmed by the RNA and protein analyses shown in Figure 2A and 2B using fetus with a homozygous deletion.
Negative_regulation (disrupted) of Ube3a
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0
These findings, together with a report by others, indicate that mice with maternal deficiency of Ube3a are a valid model for human AS with mutations in the UBE3A gene [23], [25].
Negative_regulation (deficiency) of Ube3a associated with angelman syndrome
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 1.20 Pain Relevance 0.13
These mice will be valuable for future comparative studies to mice with maternal deficiency of Ube3a alone.



Negative_regulation (deficiency) of Ube3a
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2924885 Disease Relevance 0.49 Pain Relevance 0.03
Mice with maternal deficiency of the Ube3a gene recapitulated the brain-specific imprinted expression [23], [24].
Negative_regulation (deficiency) of Ube3a in brain
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 1.43 Pain Relevance 0.12
Although Ube3a is expressed exclusively from the maternal allele in brain and, therefore, should not be affected by the Snord116 deletion on the paternal chromosome, a reduction of the paternal-specific antisense transcript Ube3aAS could potentially affect silencing of the paternal Ube3a allele and, thus, change its transcript level.
Negative_regulation (reduction) of Ube3aAS in brain
5) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.07 Pain Relevance 0

General Comments

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