INT22499

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Context Info
Confidence 0.62
First Reported 1986
Last Reported 2010
Negated 6
Speculated 6
Reported most in Abstract
Documents 42
Total Number 48
Disease Relevance 17.32
Pain Relevance 28.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
spinal cord 3
DRG 3
neurons 2
face 2
plasma 1
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 207 100.00 Very High Very High Very High
substance P 82 100.00 Very High Very High Very High
Neuropeptide 66 100.00 Very High Very High Very High
dorsal root ganglion 60 100.00 Very High Very High Very High
Pain 51 100.00 Very High Very High Very High
Inflammation 43 100.00 Very High Very High Very High
qutenza 27 100.00 Very High Very High Very High
Somatostatin 23 100.00 Very High Very High Very High
calcitonin gene related peptide 23 100.00 Very High Very High Very High
Analgesic 23 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 305 100.00 Very High Very High Very High
Neurogenic Inflammation 4 100.00 Very High Very High Very High
Pain 38 99.96 Very High Very High Very High
Nociception 43 99.84 Very High Very High Very High
Headache 5 99.80 Very High Very High Very High
INFLAMMATION 38 99.66 Very High Very High Very High
Osteoporosis 5 99.52 Very High Very High Very High
Hypoxia 14 99.48 Very High Very High Very High
Metastasis 4 99.04 Very High Very High Very High
Hypertension 2 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of calcitonin gene-related peptide (CGRP) in chronic hypoxia-induced pulmonary hypertension in the mouse.
Regulation (Role) of CGRP associated with hypoxia, hypertension and calcitonin gene-related peptide
1) Confidence 0.62 Published 2002 Journal Regul. Pept. Section Title Doc Link 12220736 Disease Relevance 0.56 Pain Relevance 0.42
Role of calcitonin gene-related peptide (CGRP) in chronic hypoxia-induced pulmonary hypertension in the mouse.
Regulation (Role) of calcitonin gene-related peptide associated with hypoxia, hypertension and calcitonin gene-related peptide
2) Confidence 0.62 Published 2002 Journal Regul. Pept. Section Title Doc Link 12220736 Disease Relevance 0.56 Pain Relevance 0.42
The mouse paw withdrawal assay: a method for determining the effect of calcitonin gene-related peptide on cutaneous heat nociceptive latency time.
Regulation (effect) of calcitonin gene-related peptide in paw associated with nociception, nociceptor, withdrawal and calcitonin gene-related peptide
3) Confidence 0.45 Published 1993 Journal Life Sci. Section Title Doc Link 8336518 Disease Relevance 0.36 Pain Relevance 0.75
We report here on the development of an assay to investigate the effect of CGRP on nociception in the dorsal hindpaw skin.
Spec (investigate) Regulation (effect) of CGRP in skin associated with nociception and calcitonin gene-related peptide
4) Confidence 0.45 Published 1993 Journal Life Sci. Section Abstract Doc Link 8336518 Disease Relevance 0.35 Pain Relevance 0.63
Effects of calcitonin gene-related peptide on acute and chronic effects of morphine.
Regulation (Effects) of calcitonin gene-related peptide associated with narcan, morphine and calcitonin gene-related peptide
5) Confidence 0.45 Published 1995 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 8545480 Disease Relevance 0.26 Pain Relevance 1.13
Calcitonin gene-related peptide (CGRP), which has been shown to modulate calcium in both the brain and in peripheral tissues, has not previously been shown to modulate calcium in the spinal cord.
Regulation (modulate) of CGRP in spinal cord associated with spinal cord and calcitonin gene-related peptide
6) Confidence 0.45 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2552070 Disease Relevance 0 Pain Relevance 0.86
Although immunoreactivity of calcitonin gene-related peptide (CGRP) was detected in mouse spinal cord, CGRP caused no behavioral reactions, nor did it significantly affect thermo- or chemonociception or the scratching induced by SP.
Regulation (immunoreactivity) of calcitonin gene-related peptide in spinal cord associated with substance p, spinal cord and calcitonin gene-related peptide
7) Confidence 0.45 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2430237 Disease Relevance 0.07 Pain Relevance 0.62
Although immunoreactivity of calcitonin gene-related peptide (CGRP) was detected in mouse spinal cord, CGRP caused no behavioral reactions, nor did it significantly affect thermo- or chemonociception or the scratching induced by SP.
Regulation (immunoreactivity) of CGRP in spinal cord associated with substance p, spinal cord and calcitonin gene-related peptide
8) Confidence 0.45 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2430237 Disease Relevance 0.07 Pain Relevance 0.62
We have previously reported a reduction of somatic withdrawal symptoms in alphaCGRP knock-out mice exposed to chronic nicotine, leading us to investigate the contribution of alphaCGRP to the regulations of ventral tegmental area (VTA) neurons and their response to nicotine.
Regulation (regulations) of alphaCGRP in neurons associated with targeted disruption, ventral tegmentum, nicotine and withdrawal
9) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18619948 Disease Relevance 0.32 Pain Relevance 0.54
Effects of calcitonin therapy on osteoporosis in patients with thalassemia.
Regulation (Effects) of calcitonin associated with pain, thalassemia and osteoporosis
10) Confidence 0.44 Published 1995 Journal Acta Haematol. Section Title Doc Link 7725845 Disease Relevance 0.72 Pain Relevance 0.28
The results suggest that the inhibitory action of CGRP in the mouse uterus is independent of the activity of these NOS isoforms.
Neg (independent) Regulation (independent) of CGRP in uterus associated with calcitonin gene-related peptide
11) Confidence 0.44 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 11058547 Disease Relevance 0.14 Pain Relevance 0.43
Taken together, these results suggest a complex role for supraspinal CGRP systems in the regulation of locomotion, nociception, and depression-like behaviors.
Regulation (role) of CGRP associated with nociception, depression and calcitonin gene-related peptide
12) Confidence 0.44 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 19381879 Disease Relevance 0.90 Pain Relevance 1.04
CGRP and CGRP receptor antagonists failed to modulate activity in the elevated plus maze, a model of anxiety.
Neg (failed) Regulation (modulate) of CGRP associated with antagonist, anxiety disorder and calcitonin gene-related peptide
13) Confidence 0.44 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 19381879 Disease Relevance 0.83 Pain Relevance 1.09
CGRP and CGRP receptor antagonists failed to modulate activity in the elevated plus maze, a model of anxiety.
Neg (failed) Regulation (modulate) of CGRP associated with antagonist, anxiety disorder and calcitonin gene-related peptide
14) Confidence 0.44 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 19381879 Disease Relevance 0.83 Pain Relevance 1.09
We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis).
Spec (examined) Regulation (effects) of calcitonin in tail associated with nociception, substance p and intrathecal
15) Confidence 0.44 Published 1994 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 7531982 Disease Relevance 0.09 Pain Relevance 0.19
The effect of neonatal capsaicin treatment on the CGRP-immunoreaction in the trigeminal subnucleus caudalis of mice.
Regulation (effect) of CGRP associated with qutenza
16) Confidence 0.44 Published 2008 Journal Biomed. Res. Section Title Doc Link 18344596 Disease Relevance 0.22 Pain Relevance 0.67
The major migraine mediator calcitonin gene-related peptide (CGRP) is known to sensitize P2X(3) receptors to increase impulse flow to brainstem trigeminal nuclei.
Regulation (sensitize) of calcitonin gene-related peptide in brainstem associated with medulla, migraine and calcitonin gene-related peptide
17) Confidence 0.43 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.55 Pain Relevance 0.67
To study the downstream effects of nNOS deficiency on DRG neurones, we assessed their immunoreactivity for calcitonin gene-related peptide (CGRP) and cytokines.
Regulation (immunoreactivity) of CGRP in DRG associated with cytokine and calcitonin gene-related peptide
18) Confidence 0.41 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17395508 Disease Relevance 0.79 Pain Relevance 0.72
To study the downstream effects of nNOS deficiency on DRG neurones, we assessed their immunoreactivity for calcitonin gene-related peptide (CGRP) and cytokines.
Regulation (immunoreactivity) of calcitonin gene-related peptide in DRG associated with cytokine and calcitonin gene-related peptide
19) Confidence 0.41 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17395508 Disease Relevance 0.78 Pain Relevance 0.72
The aim of this paper is to study the influence of salmon calcitonin (SCT) on opioid analgesia when opioid transduction pathways are functionally uncoupled from Gi/o proteins by treatment with pertussis toxin (PTX).
Regulation (influence) of calcitonin associated with bordatella infection, opioid and analgesia
20) Confidence 0.37 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10515187 Disease Relevance 0.17 Pain Relevance 0.98

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