INT22500

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.41
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth)
Anatomy Link Frequency
parathyroid 2
Pth (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
antinociception 12 98.68 Very High Very High Very High
imagery 1 95.44 Very High Very High Very High
tail-flick 6 95.12 Very High Very High Very High
Antinociceptive 12 94.08 High High
narcan 2 90.20 High High
Morphine 10 89.60 High High
tolerance 3 85.16 High High
cytokine 14 78.24 Quite High
rheumatoid arthritis 33 71.96 Quite High
Disease Link Frequency Relevance Heat
Parathyroid Cancer 2 99.96 Very High Very High Very High
Kidney Stones 5 99.82 Very High Very High Very High
Hypophosphatemia 13 92.04 High High
Systemic Lupus Erythematosus 13 90.84 High High
Chronic Renal Failure 3 90.12 High High
Autoimmune Disease 2 89.52 High High
Rickets 89 84.28 Quite High
Hypercalcemia 30 84.16 Quite High
Hyperalgesia 4 83.12 Quite High
Cancer 17 81.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[tyrosine-34]b-PTH (7-34)NH2, the PTH antagonist, did not block PTH 1-34-induced antinociception.
Negative_regulation (antagonist) of PTH associated with antinociception and antagonist
1) Confidence 0.43 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2299586 Disease Relevance 0.08 Pain Relevance 1.15
The latter increases both calcium and phosphate intestinal absorption, which results in hypercalciuria and the suppression of PTH.
Negative_regulation (suppression) of PTH associated with kidney stones
2) Confidence 0.38 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.36 Pain Relevance 0
[tyrosine-34]b-PTH (7-34)NH2, the PTH antagonist, did not block PTH 1-34-induced antinociception.
Negative_regulation (antagonist) of b-PTH associated with antinociception and antagonist
3) Confidence 0.38 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2299586 Disease Relevance 0.08 Pain Relevance 1.16
Until the results of this trial are published, this author suggests that replacement of 25(OH)D to levels greater than 32 ng/mL should maximize the absorption of calcium from the gastrointestinal tract with reasonable suppression of serum PTH levels.


Negative_regulation (suppression) of serum PTH
4) Confidence 0.32 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.49 Pain Relevance 0.04
These recommendations are based on the amount of vitamin D that is needed to maximally suppress PTH (1–84) secretion [22], but there is no consensus, as some investigators advocate that the 25(OH)2D level needed to maximally suppress PTH is 30 to 44 ng/mL [23].
Negative_regulation (suppress) of PTH
5) Confidence 0.32 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0 Pain Relevance 0
After surgical removal of the parathyroid adenoma, PTH levels decreased to 212 pg/ml.
Negative_regulation (decreased) of PTH in parathyroid associated with parathyroid cancer
6) Confidence 0.23 Published 2010 Journal ScientificWorldJournal Section Abstract Doc Link 20454761 Disease Relevance 0.86 Pain Relevance 0.17
Moreover, combined use of OPG and parathyroid hormone in ovariectomized rats has shown an additive effect in preventing bone loss, suggesting a potential therapeutic use of intermittent OPG and parathyroid hormone to reverse both generalized and localized bone loss [62].
Negative_regulation (use) of parathyroid hormone in parathyroid
7) Confidence 0.03 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.52 Pain Relevance 0.32

General Comments

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