INT225019

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.54
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB, Cxcl1) extracellular space (Cxcl1) cytoplasm (PDGFB)
PDGFB (Homo sapiens)
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 108 98.68 Very High Very High Very High
Inflammation 12 93.32 High High
Glutamate 8 78.60 Quite High
cytokine 8 33.60 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 93.32 High High
Wound Healing 8 71.40 Quite High
Cancer 4 44.60 Quite Low
Injury 12 5.00 Very Low Very Low Very Low
Myocardial Infarction 8 5.00 Very Low Very Low Very Low
Diabetic Foot Ulcer 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although PDGF induced expression of CXCL1, 2, and 5, the effects of these chemokines on PDGF function in vivo are still unclear.
PDGF Positive_regulation (induced) of Gene_expression (expression) of CXCL1 associated with chemokine
1) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.05 Pain Relevance 0.28
In contrast, CXCL1 gene expression induced by 2.5 µg PDGF encapsulated in low MW and high MW PLGA microspheres had no significant differences from either the NFS alone or PDGF coating groups, which indicates up-regulation of CXCL1 gene expression stimulated by PDGF is dependent on PDGF dose.
PDGF Positive_regulation (stimulated) of Gene_expression (expression) of CXCL1 gene
2) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.18 Pain Relevance 0.36
The CXCL1 gene expression induced by 25 µg PDGF encapsulated in low MW and high MW PLGA microspheres was higher than that in the scaffold alone group, PDGF coating group, and low dose PDGF microsphere group.
PDGF Positive_regulation (induced) of Gene_expression (expression) of CXCL1 gene
3) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.23 Pain Relevance 0.45
However, the gene expression of CXCL1, 2, 5, and CCL21b induced by 25 µg PDGF coated on PLLA scaffolds (not encapsulated in PLGA microspheres) was not different from that by the empty scaffolds or 2.5 µg (low dose) PDGF microsphere groups, which suggests that PDGF release from PDGF-coated scaffolds may be too rapid to be effective.
PDGF Positive_regulation (induced) of Gene_expression (expression) of CXCL1
4) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.07 Pain Relevance 0.30

General Comments

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