INT22502

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Context Info
Confidence 0.53
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 9.80
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Hal) biosynthetic process (Hal) cytoplasm (Hal)
Anatomy Link Frequency
neuronal 1
ventricle 1
superior 1
nucleus 1
white matter 1
Hal (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 14 99.82 Very High Very High Very High
antagonist 8 99.32 Very High Very High Very High
cva 44 98.44 Very High Very High Very High
Multiple sclerosis 1 96.16 Very High Very High Very High
Analgesic 4 96.08 Very High Very High Very High
lidocaine 1 94.32 High High
Neuritis 1 93.80 High High
Serotonin 23 90.56 High High
withdrawal 8 88.80 High High
Dopamine 103 85.88 High High
Disease Link Frequency Relevance Heat
Renal Disease 4 99.92 Very High Very High Very High
Hypoxia 8 99.36 Very High Very High Very High
Arrhythmias 2 Under Development 86 99.16 Very High Very High Very High
Hemorrhage 60 98.44 Very High Very High Very High
Cv General 3 Under Development 8 98.16 Very High Very High Very High
Hallucination 4 98.16 Very High Very High Very High
Tuberous Sclerosis 1 97.52 Very High Very High Very High
Coronary Heart Disease 2 96.96 Very High Very High Very High
Hypertension 8 96.80 Very High Very High Very High
Demyelinating Disease 4 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
He published approximately 100 works in the field of clinical neurology, neuropathology, psychiatry, and forensic psychiatry, His works on cortical presentation of the body scheme, hallucinations, tuberous sclerosis, pregnancy and multiple sclerosis, pathohistology of demyelisation, toxic neuritis, epilepsies, nervous manifestations of Malta fever, herpetic infections, pathogenesis of convulsive syndromes, psychiatric terminology, therapies of Parkinson disease and schizophrenia, ability of making will, organization of the psychiatric service, were published in national and prestigious European journals, and often cited.
Gene_expression (works) of His in body associated with parkinson's disease, hallucination, syndrome, brucella infection, tuberous sclerosis, herpes simplex virus infection, neuritis, schizophrenia, infection, epilepsy and multiple sclerosis
1) Confidence 0.53 Published 2008 Journal Lijec Vjesn Section Abstract Doc Link 19062762 Disease Relevance 1.09 Pain Relevance 0.14
Electrophysiology study suggested that the damaged structure might be the bundle of His.
Gene_expression (bundle) of His
2) Confidence 0.53 Published 2009 Journal Circ. J. Section Abstract Doc Link 19075523 Disease Relevance 0.94 Pain Relevance 0.09
Cocaine rapidly produced severe prolongation of His to ventricle interval and widening of the R wave.
Gene_expression (produced) of His in ventricle associated with cocaine
3) Confidence 0.46 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2299588 Disease Relevance 0.29 Pain Relevance 0.63
Our results showed that AMPH significantly lowered peak HTO frequencies in WT animals treated with HAL (WT/HAL and AMPH: 5.9±0.2 Hz; tstat1,8?
Gene_expression (treated) of HAL
4) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.35 Pain Relevance 0.20
Our results showed that AMPH significantly lowered peak HTO frequencies in WT animals treated with HAL (WT/HAL and AMPH: 5.9±0.2 Hz; tstat1,8?
Gene_expression (/) of HAL
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.36 Pain Relevance 0.18
Our results showed that AMPH significantly lowered peak HTO frequencies in WT animals treated with HAL (WT/HAL and AMPH: 5.9±0.2 Hz; tstat1,8?
Gene_expression (/) of HAL
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.36 Pain Relevance 0.18
Firstly, WT animals were treated with both HAL and AMPH, and electrophysiological data was collected during the 2-hour recording period.
Gene_expression (treated) of HAL
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.30 Pain Relevance 0.21
Our results showed that AMPH significantly lowered peak HTO frequencies in WT animals treated with HAL (WT/HAL and AMPH: 5.9±0.2 Hz; tstat1,8?
Gene_expression (treated) of HAL
8) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.36 Pain Relevance 0.20
Both CLZ and QUE, but not HAL, protect the white matter in CP of mice exposed to CPZ (Figures 6 and 7), suggesting that additional mechanisms are involved in the protective effect of these two SGAs besides the anti-dopaminergic action shared by all the three antipsychotics as discussed above.
Gene_expression (protect) of HAL in white matter
9) Confidence 0.40 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.09 Pain Relevance 0.03
In the HAL experiment (Figures 2A,B), CPZ-exposure for 21?
Gene_expression (experiment) of HAL
10) Confidence 0.40 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0
Moreover, HAL alone (for 42?
Gene_expression (Moreover) of HAL
11) Confidence 0.40 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0.03
Another problem was detected when approximately half the maternal deaths declared in the MIS could not be found in the HIS, another aspect of this study that has already been reported [16].
Neg (not) Gene_expression (found) of HIS
12) Confidence 0.35 Published 2008 Journal Reprod Health Section Body Doc Link PMC2583985 Disease Relevance 0.38 Pain Relevance 0.05
Spatiotemporal IOS analysis revealed that in infant brain stem, HSD was preferably ignited within the spinal trigeminal nucleus and then mostly spread out medially, invading the hypoglossal nucleus, the nucleus of the solitary tract (NTS), and the ventral respiratory group (VRG).
Gene_expression (spread) of HSD in nucleus
13) Confidence 0.08 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19261708 Disease Relevance 0.92 Pain Relevance 0.38
The neuronal hypoxic depolarizations underlying the generation of HSD were massive, but incomplete.
Gene_expression (generation) of HSD in neuronal associated with hypoxia
14) Confidence 0.07 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19261708 Disease Relevance 0.93 Pain Relevance 0.41
Both his receptive and expressive speech are delayed, and he has only a few words.
Gene_expression (expressive) of his
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929201 Disease Relevance 0.99 Pain Relevance 0
-catenin regulation in fracture repair, we used an adenovirus expressing a His-tagged DKK1, an antagonist of canonical WNT/?
Gene_expression (expressing) of His associated with antagonist
16) Confidence 0.05 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.28 Pain Relevance 0.09
The pioneer JF Swartz stopped his efforts in ablating chronic atrial fibrillation after two of his 36 patients developed severe cerebrovascular insults.
Gene_expression (efforts) of his associated with arrhythmias 2 under development
17) Confidence 0.04 Published 2002 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1569901 Disease Relevance 0.37 Pain Relevance 0.05
Their main findings were:

• HS allows complete haemodynamic resuscitation using smaller volumes. • Resuscitation is sustained longer using HSD. • Recovery of renal and mesenteric blood is rapid and with no concomitant pulmonary hypertension using HSD. • HSD maintains its haemodynamic effects longest post cessation of fluid administration. • Sodium concentration and osmolality were not problematic using HS or HSD.

Gene_expression (using) of HSD associated with hypertension
18) Confidence 0.03 Published 2003 Journal Crit Care Section Body Doc Link PMC270728 Disease Relevance 0.43 Pain Relevance 0
The combination of increased recruitment of fluid to the intravascular space associated with decreased rebreeding volumes makes HSD, in the present model of uncontrolled hemorrhage, superior to LR resuscitation.



Gene_expression (makes) of HSD in superior associated with cva
19) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2815285 Disease Relevance 0.48 Pain Relevance 0.14
His serum was negative for rheumatoid factor, antinuclear factors and antineutrophil cytoplasmic antibodies.
Neg (negative) Gene_expression (negative) of His
20) Confidence 0.01 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2918613 Disease Relevance 0.90 Pain Relevance 0.05

General Comments

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