INT22503

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Context Info
Confidence 0.36
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.44
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Hal) biosynthetic process (Hal) cytoplasm (Hal)
Anatomy Link Frequency
brain stem 2
Hal (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 2 99.96 Very High Very High Very High
tetrodotoxin 9 99.40 Very High Very High Very High
Migraine 4 98.40 Very High Very High Very High
cva 50 97.52 Very High Very High Very High
cocaine 14 94.00 High High
depression 7 93.84 High High
GABAergic 2 92.20 High High
antagonist 1 91.80 High High
dopamine receptor 3 91.36 High High
Hippocampus 8 89.88 High High
Disease Link Frequency Relevance Heat
Hypoxia 8 99.58 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 17 98.92 Very High Very High Very High
Targeted Disruption 75 98.76 Very High Very High Very High
Headache 4 98.40 Very High Very High Very High
Hemorrhage 96 97.52 Very High Very High Very High
Heart Rate Under Development 2 97.00 Very High Very High Very High
Increased Venous Pressure Under Development 2 96.36 Very High Very High Very High
Sudden Infant Death Syndrome 2 95.12 Very High Very High Very High
Depression 7 93.84 High High
Poisoning 2 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Slowing of conduction was dose-dependent, with maximal increases in His to venticle interval of 37 to 56% (P = .0299) and R wave duration of 34 to 77% (P less than .025).
Positive_regulation (increases) of His
1) Confidence 0.36 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2299588 Disease Relevance 0.29 Pain Relevance 0.62
HAL attenuated behavioral hyperactivity (see Fig. 2F) and novelty-induced peak HTO frequency increases in both WT (vehicle: 8.0±0.1 Hz, HAL: 6.5±0.2 Hz; Fig. 2A) and DAT-KO mice (vehicle: 8.0±0.1 Hz, HAL: 6.3±0.1 Hz; Fig. 2B).
Positive_regulation (increases) of HAL associated with targeted disruption and attention deficit hyperactivity disorder
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.79 Pain Relevance 0.17
The preferred occurrence of HSD in the infant brain stem and its propagation into the VRG may be of importance for neonatal brain stem pathology such as sudden infant death syndrome.
Positive_regulation (occurrence) of HSD in brain stem associated with sudden infant death syndrome
3) Confidence 0.06 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19261708 Disease Relevance 0.62 Pain Relevance 0.24
In rat brain stem slices, severe hypoxia (oxygen withdrawal) triggered HSD within minutes.
Positive_regulation (triggered) of HSD in brain stem associated with hypoxia and withdrawal
4) Confidence 0.06 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19261708 Disease Relevance 0.92 Pain Relevance 0.39
Does exogenous FLAG-CRIF1 affect the accumulation of exogenous His-V5-NRF2 at the enhancer region of HO-1?
Positive_regulation (accumulation) of His
5) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
MAP increased in the HSD and LR groups to levels slightly higher than those in the NT group up to T45, most likely due to fluid infusion.
Positive_regulation (increased) of HSD
6) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2815285 Disease Relevance 0.83 Pain Relevance 0.03
It increased in HSD-treated animals and decreased significantly in the LR group (p<0.05 NT and HSD vs.
Positive_regulation (increased) of HSD
7) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2815285 Disease Relevance 0.99 Pain Relevance 0.08
Ouabain inhibited CuHis stimulation of LHRH release by 80%, whereas TTX and amiloride were ineffective.
Positive_regulation (stimulation) of CuHis associated with tetrodotoxin
8) Confidence 0.00 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027598 Disease Relevance 0 Pain Relevance 0.29
To gain further understanding of the mechanism of copper action, in this study, we assessed the Na+ and energy requirements for CuHis stimulation of LHRH release.
Positive_regulation (stimulation) of CuHis
9) Confidence 0.00 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027598 Disease Relevance 0 Pain Relevance 0
To assess the requirement for Na+ transport, we evaluated the effect of 1 mM ouabain, 10 microM tetrodotoxin (TTX), or 100 microM amiloride on CuHis stimulation of LHRH release.
Positive_regulation (stimulation) of CuHis associated with tetrodotoxin
10) Confidence 0.00 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3027598 Disease Relevance 0 Pain Relevance 0.29

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