INT225065

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FANCB) cytosol (ETF1) RNA binding (ETF1)
nucleus (FANCB) translation (ETF1) cytoplasm (ETF1)
ETF1 (Homo sapiens)
FANCB (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 4 100.00 Very High Very High Very High
Chronic pancreatitis 20 84.24 Quite High
alcohol 4 78.56 Quite High
Arthritis 4 71.44 Quite High
imagery 12 70.96 Quite High
Inflammatory response 4 67.48 Quite High
Inflammation 16 61.16 Quite High
fibrosis 8 5.00 Very Low Very Low Very Low
Prostatitis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 8 100.00 Very High Very High Very High
Autoimmune Disease 28 95.64 Very High Very High Very High
Pancreatitis 132 92.64 High High
Alcohol Addiction 4 78.56 Quite High
INFLAMMATION 20 67.12 Quite High
Targeted Disruption 4 60.52 Quite High
Pressure And Volume Under Development 8 52.96 Quite High
Disease 44 49.52 Quite Low
Hypergammaglobulinemia 4 44.32 Quite Low
Injury 4 26.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It should be also reminded that a previous report, albeit in vitro, did show through domain swapping experiments that the binding of a monoclonal IgG4 RF (isolated this time from a rheumatoid arthritis patient) to IgG is through their respective constant segments and not Fab-Fc [40].
RF Binding (binding) of Fab associated with rheumatoid arthritis
1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.17 Pain Relevance 0.09
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
RF Binding (recognizes) of Fab
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.89 Pain Relevance 0.22
This Fc-Fc interaction departs from the present definition of RF as a Fab-Fc interaction hence the proposed dichotomic nomenclature of CRF vs.
RF Binding (interaction) of Fab
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.13 Pain Relevance 0.06
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
RF Binding (recognizes) of Fab
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.89 Pain Relevance 0.22

General Comments

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