INT225082

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.60
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
IGHG3 (Homo sapiens)
fc (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 100.00 Very High Very High Very High
Inflammation 24 98.36 Very High Very High Very High
Chronic pancreatitis 30 84.80 Quite High
alcohol 6 79.12 Quite High
imagery 18 71.52 Quite High
Arthritis 6 71.44 Quite High
Pain 1 56.56 Quite High
Inflammatory response 6 22.64 Low Low
fibrosis 12 5.00 Very Low Very Low Very Low
Prostatitis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 12 100.00 Very High Very High Very High
Injury 6 99.72 Very High Very High Very High
INFLAMMATION 30 98.36 Very High Very High Very High
Autoimmune Disease 42 95.36 Very High Very High Very High
Pancreatitis 198 93.20 High High
Sprains And Strains 16 92.56 High High
Renal Disease 6 90.12 High High
Drug-induced Liver Injury 6 80.80 Quite High
Hepatitis 12 79.20 Quite High
Alcohol Addiction 6 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IgG4 Fc-Fc binding may therefore indeed induce aggregation of immunoglobulins.
IgG4 Binding (binding) of Fc
1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.66 Pain Relevance 0.09
These results collectively indicate that the Fc portion of IgG4, rather than the Fab portion, binds to IgG Fc, and that the binding of IgG4 to IgG is not attributable to the autoantibody activity of IgG4 i.e. via Fab.
IgG Binding (binds) of Fc
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.19 Pain Relevance 0
In more general terms and despite the fact that is is likely premature to speculate much on the physiological/pathological effects of IgG4 Fc-IgG Fc complexes in vivo, several not exclusive situations could be envisioned based on circumstantial evidences. (1) IgG4 Fc-Fc binding may have a pathological role within the inflammatory process, or even induce inflammation per se.
IgG4 Binding (binding) of Fc associated with inflammation
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.92 Pain Relevance 0.10
Having established that IgG4 recognizes IgG Fc, we next examined whether IgG4's Fc or Fab portion reacts to IgG Fc.
IgG4 Spec (examined) Binding (recognizes) of Fc
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.25 Pain Relevance 0
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
IgG Binding (recognizes) of Fc
5) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.94 Pain Relevance 0.22
It should be also reminded that a previous report, albeit in vitro, did show through domain swapping experiments that the binding of a monoclonal IgG4 RF (isolated this time from a rheumatoid arthritis patient) to IgG is through their respective constant segments and not Fab-Fc [40].
IgG Binding (binding) of Fc associated with rheumatoid arthritis
6) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.17 Pain Relevance 0.09
There are two kinds of Mac produced by GAS isolates [7], which use different mechanisms to block the interaction between IgG and Fc receptor on the surface of PMNs.
IgG Binding (interaction) of Fc
7) Confidence 0.01 Published 2010 Journal The Open Microbiology Journal Section Body Doc Link PMC2885601 Disease Relevance 0.47 Pain Relevance 0.06

General Comments

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