INT22509

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C6) extracellular region (C6) molecular_function (C6)
Anatomy Link Frequency
spinal cord 1
C6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 98.78 Very High Very High Very High
Pain 3 98.64 Very High Very High Very High
spinal cord stimulator 1 97.60 Very High Very High Very High
Spinal cord 57 76.28 Quite High
potassium channel 1 75.00 Quite High
Angina 1 25.00 Low Low
Central nervous system 29 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 3 98.64 Very High Very High Very High
Injury 57 81.80 Quite High
Spinal Cord Injury 70 76.28 Quite High
Hypertension 1 25.00 Low Low
Central Nervous System Disease 28 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low
Cicatrix 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Strongly electron-withdrawing substituents at the C-6 position are required for optimal activity.
Positive_regulation (required) of C-6
1) Confidence 0.43 Published 1990 Journal J. Med. Chem. Section Abstract Doc Link 2299619 Disease Relevance 0 Pain Relevance 0.04
Electrical stimulation of the C6 and C7 nerve roots was accomplished using a four-electrode spinal cord stimulator lead that was placed percutaneously within the exit zone of the neuroforamina using an extra-foraminal approach.
Positive_regulation (stimulation) of C6 in spinal cord associated with spinal cord stimulator
2) Confidence 0.40 Published 2004 Journal Pain Physician Section Abstract Doc Link 16868619 Disease Relevance 0.19 Pain Relevance 0.32
These studies suggested that cell lysates and supernatant collected from cultured PMNs that were exposed to cytokines or C. albicans hyphae opsonized with normal human serum had elevated levels of C6 and C7 proteins [18,19]; however, it was not conclusive that these proteins were produced by PMNs in culture because (1) the rise in C6 or C7 in culture could have been released by C. albicans hyphae or derived from normal human serum, (2) the inhibition of protein biosynthesis by cycloheximide did not affect the rise in C6 or C7 in PMN cultures [18], and (3) conclusive evidence showing that PMNs are actively expressing these terminal complement mRNAs or proteins has been lacking in the literature.
Positive_regulation (elevated) of C6 associated with cytokine
3) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.29 Pain Relevance 0.15

General Comments

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