INT225094

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.89
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
HGF 1
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
rheumatoid arthritis 152 99.84 Very High Very High Very High
Osteoarthritis 54 99.52 Very High Very High Very High
Inflammation 22 85.48 High High
antagonist 16 61.76 Quite High
amygdala 1 43.44 Quite Low
Anterior cingulate cortex 1 42.64 Quite Low
insula 2 40.48 Quite Low
Thalamus 1 39.84 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 152 99.84 Very High Very High Very High
Osteoarthritis 54 99.52 Very High Very High Very High
Adhesions 150 94.48 High High
Systemic Sclerosis 2 86.76 High High
Systemic Lupus Erythematosus 2 86.12 High High
Disease 30 85.84 High High
Myocardial Infarction 209 85.72 High High
INFLAMMATION 21 85.48 High High
Apoptosis 5 84.80 Quite High
Injury 1 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adrenomedullin was secreted by RA-FLSs and may act as a soluble factor.
Localization (secreted) of Adrenomedullin associated with rheumatoid arthritis
1) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.42 Pain Relevance 0.57
Adrenomedullin, a peptide with anabolic and antiapoptotic properties, is secreted by rheumatoid FLSs.
Localization (secreted) of Adrenomedullin
2) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991025 Disease Relevance 0.68 Pain Relevance 0.24
Indirect quantification of this peptide can be made by measuring the mid-regional fragment of the proAdrenomedullin peptide, which is more stable and secreted in equimolar concentrations as ADM.
Localization (secreted) of proAdrenomedullin
3) Confidence 0.44 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.88 Pain Relevance 0
However, orthogonal contrasts indicated that significant differences between FDI and ADM were found comparing Bombolone to Salame (p?
Localization (differences) of ADM
4) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253499 Disease Relevance 0.06 Pain Relevance 0
Indirect quantification of this peptide can be made by measuring the mid-regional fragment of the proAdrenomedullin peptide, which is more stable and secreted in equimolar concentrations as ADM.
Localization (secreted) of ADM
5) Confidence 0.38 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.77 Pain Relevance 0
BMMC and MSC have been extensively studied and proved to produce and secrete a broad variety of cytokines, chemokines, and growth factors, between them VEGF, FGF, HGF, IGF, adrenomedullin, thymosin ?
Localization (secrete) of adrenomedullin in HGF associated with chemokine and cytokine
6) Confidence 0.16 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.08 Pain Relevance 0.10

General Comments

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