INT225098

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF630, TGFB1) aging (TGFB1) intracellular (ZNF630)
enzyme binding (TGFB1) embryo development (TGFB1) DNA binding (ZNF630)
ZNF630 (Homo sapiens)
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 99.02 Very High Very High Very High
cytokine 10 96.82 Very High Very High Very High
chemokine 3 75.24 Quite High
Endocannabinoid 24 72.48 Quite High
antagonist 23 65.24 Quite High
Cannabinoid 26 50.00 Quite Low
Inflammation 13 50.00 Quite Low
fibrosis 12 50.00 Quite Low
Cannabinoid receptor 18 46.88 Quite Low
Chronic pancreatitis 31 29.60 Quite Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 44 73.12 Quite High
Apoptosis 11 68.92 Quite High
Death 2 59.12 Quite High
INFLAMMATION 14 50.00 Quite Low
Fibrosis 11 50.00 Quite Low
Necrosis 3 48.08 Quite Low
Pancreatitis 32 29.60 Quite Low
Cirrhosis 15 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Keloid Scars 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a next step, the profibrogenic cytokine TGFbeta, which stimulates the synthesis and secretion of fibronectin, collagen1 and matrix metalloproteinases, was analyzed, revealing that neither AM251 nor AM630 significantly altered secreted TGFbeta levels (Figure 3E).
AM630 Neg (neither) Regulation (altered) of Neg (neither) Localization (secreted) of TGFbeta associated with metalloproteinase and cytokine
1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.44 Pain Relevance 0.24

General Comments

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