INT225099

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.20

extracellular space (COL1A1) extracellular region (COL1A1) nucleus (ZNF630) intracellular (ZNF630) DNA binding (ZNF630) cytoplasm (COL1A1)

ZNF630 (Homo sapiens) COL1A1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 3 85.32 cytokine 10 80.92 chemokine 3 62.52 Endocannabinoid 24 59.76 antagonist 23 52.52 Cannabinoid 26 50.00 Inflammation 13 50.00 fibrosis 12 50.00 Cannabinoid receptor 18 34.16 Chronic pancreatitis 31 16.88

Disease Link Frequency Relevance Heat Primary Sclerosing Cholangitis 44 60.40 Apoptosis 11 56.20 INFLAMMATION 14 50.00 Fibrosis 11 50.00 Death 2 46.40 Necrosis 3 35.36 Pancreatitis 32 16.88 Cirrhosis 15 5.00 Disease 6 5.00 Keloid Scars 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blockade of the CB2-receptor by AM630 did also not change collagen 1 and fibronectin production (Figure 4).

AM630 Neg (not) Positive_regulation (change) of Gene_expression (production) of collagen 1

1) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.17 Pain Relevance 0.20

General Comments

This test has worked.