INT225101

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (TGFB1, COL1A1) extracellular space (TGFB1, COL1A1) extracellular region (TGFB1, COL1A1)
aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
TGFB1 (Homo sapiens)
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 99.98 Very High Very High Very High
metalloproteinase 3 99.52 Very High Very High Very High
chemokine 3 81.56 Quite High
Endocannabinoid 24 78.80 Quite High
antagonist 23 71.56 Quite High
Cannabinoid receptor 18 53.20 Quite High
Cannabinoid 26 50.00 Quite Low
Inflammation 13 50.00 Quite Low
fibrosis 12 50.00 Quite Low
Chronic pancreatitis 31 35.92 Quite Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 44 79.44 Quite High
Apoptosis 11 75.24 Quite High
Death 2 65.44 Quite High
Necrosis 3 54.40 Quite High
INFLAMMATION 14 50.00 Quite Low
Fibrosis 11 50.00 Quite Low
Pancreatitis 32 35.92 Quite Low
Cirrhosis 15 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Keloid Scars 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a next step, the profibrogenic cytokine TGFbeta, which stimulates the synthesis and secretion of fibronectin, collagen1 and matrix metalloproteinases, was analyzed, revealing that neither AM251 nor AM630 significantly altered secreted TGFbeta levels (Figure 3E).
TGFbeta Positive_regulation (stimulates) of Localization (secretion) of collagen1 associated with metalloproteinase and cytokine
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.59 Pain Relevance 0.28

General Comments

This test has worked.

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