INT225158

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.26
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK2, CDKN1A) cytoplasm (CDK2, CDKN1A) cytosol (CDK2, CDKN1A)
nucleus (CDK2, CDKN1A) cell cycle (CDK2, CDKN1A) kinase activity (CDK2, CDKN1A)
CDK2 (Homo sapiens)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 54 99.84 Very High Very High Very High
Enkephalin 12 74.56 Quite High
Opioid 78 73.04 Quite High
corticosteroid 1 72.96 Quite High
antagonist 61 64.64 Quite High
Bile 2 11.44 Low Low
opioid receptor 48 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 6 97.32 Very High Very High Very High
Retinoblastoma 157 90.68 High High
Prostate Cancer 11 88.76 High High
Apoptosis 54 87.76 High High
Adenocarcinoma 20 85.44 High High
Lung Cancer 8 83.12 Quite High
Cancer 203 80.96 Quite High
Pancreatic Cancer 212 79.76 Quite High
Death 14 71.64 Quite High
Breast Cancer 17 42.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because p21 inhibits Cdk2 by physical interaction, we examined whether the OGF-induced downregulation of Cdk2 kinase activity was based on p21/Cdk2 complex formation.
Cdk2 Binding (formation) of p21
1) Confidence 0.30 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0 Pain Relevance 0.25
This reduction in Cdk2 kinase activity correlated with an increase in Cdk2/p21 complex formation in the OGF-exposed cells relative to control cultures at all time points.
Cdk2 Binding (formation) of p21
2) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
OGF treatment increased cyclin-dependent kinase inhibitor (CKI) p21 protein expression in comparison to controls, as well levels of p21 complexed with Cdk2.
Cdk2 Binding (complexed) of p21
3) Confidence 0.29 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2253554 Disease Relevance 0.69 Pain Relevance 0.20
This reduction in Cdk2 kinase activity correlated with an increase in Cdk2/p21 complex formation in the OGF-exposed cells relative to control cultures at all time points.
Cdk2 Binding (formation) of p21
4) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
Because p21 inhibits Cdk2 by physical interaction, we examined whether the OGF-induced downregulation of Cdk2 kinase activity was based on p21/Cdk2 complex formation.
Cdk2 Binding (formation) of p21
5) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0 Pain Relevance 0.25
Because p21 inhibits Cdk2 by physical interaction, we examined whether the OGF-induced downregulation of Cdk2 kinase activity was based on p21/Cdk2 complex formation.
Cdk2 Binding (formation) of p21
6) Confidence 0.29 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0 Pain Relevance 0.25
A cytostatic effect of mifepristone has also been shown in ovarian cancer cells by blocking DNA synthesis and cell cycle arrest at the G1-S transition via reduction of cdk2 activity, likely due to increased cdk2 association with cdk inhibitors p21 and -27 and reduced nuclear cdk2/cyclin E complex availability [383].
cdk2 Spec (likely) Binding (association) of p21 associated with ovarian cancer
7) Confidence 0.08 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.83 Pain Relevance 0.07

General Comments

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