INT22516

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Context Info
Confidence 0.25
First Reported 1988
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 2.98
Pain Relevance 13.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 6
brain 2
tube 1
spleen 1
amniotic fluid 1
H2-M3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 178 100.00 Very High Very High Very High
Calcium channel 2 98.40 Very High Very High Very High
Neurotransmitter 1 98.24 Very High Very High Very High
anesthesia 5 98.16 Very High Very High Very High
Bioavailability 3 98.04 Very High Very High Very High
halothane 11 97.94 Very High Very High Very High
agonist 1 96.74 Very High Very High Very High
Perioperative pain 1 96.08 Very High Very High Very High
tetrodotoxin 1 95.34 Very High Very High Very High
addiction 2 94.36 High High
Disease Link Frequency Relevance Heat
Post Operative Pain 1 96.08 Very High Very High Very High
Ulcers 5 94.76 High High
Convulsion 4 93.36 High High
Aging 8 87.80 High High
Respiratory Failure 12 87.36 High High
Renal Failure 10 84.36 Quite High
Cancer Pain 2 83.92 Quite High
Myoclonus 4 79.68 Quite High
Neuropathic Pain 2 78.56 Quite High
Skin Ulcer 2 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M6G and M3G are present for longer time periods and in higher concentrations than the parent drug, but their potential contribution to reward and to development of dependence and addiction is not clear.
Gene_expression (present) of M3G associated with addiction
1) Confidence 0.25 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19351545 Disease Relevance 0 Pain Relevance 0.78
The present study determined the effect of halothane on the disposition of morphine by defining the effect of halothane anesthesia on the systemic, renal, and hepatic clearance of the parent compound, morphine, and on the generation of the primary metabolite, morphine-3-glucuronide (M3G) in the dog.
Gene_expression (generation) of M3G associated with anesthesia, halothane and morphine
2) Confidence 0.15 Published 1990 Journal Anesthesiology Section Abstract Doc Link 2301762 Disease Relevance 0 Pain Relevance 1.37
The time course and extent of morphine-3-beta-D-glucuronide (M3G) production from morphine (MOR) and the clearance of M3G from plasma was studied in the late gestation fetal lamb.
Gene_expression (production) of M3G in plasma associated with morphine
3) Confidence 0.08 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3183953 Disease Relevance 0.07 Pain Relevance 0.59
M3G was produced in the fetal lamb and accumulated extensively in fetal plasma and amniotic fluid.
Gene_expression (produced) of M3G in amniotic fluid
4) Confidence 0.08 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3183953 Disease Relevance 0.09 Pain Relevance 0.72
The time course and extent of morphine-3-beta-D-glucuronide (M3G) production from morphine (MOR) and the clearance of M3G from plasma was studied in the late gestation fetal lamb.
Gene_expression (production) of M3G in plasma associated with morphine
5) Confidence 0.07 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3183953 Disease Relevance 0.08 Pain Relevance 0.60
Following morphine intake in humans, the metabolites morphine-3-glucuronide (M3G) and M6G are present in substantial concentrations and for longer periods than the parent drug.
Gene_expression (present) of M3G associated with morphine
6) Confidence 0.05 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17011617 Disease Relevance 0.10 Pain Relevance 1.03
A recombinant single-chain variable fragment (scFv) antibody to morphine-3-glucuronide (M3G) was produced using genetic material obtained from the spleen cells of mice immunised with a morphine-3-glucuronide-bovine serum albumin (M3G-BSA) conjugate.
Gene_expression (produced) of M3G in spleen associated with morphine
7) Confidence 0.05 Published 2003 Journal J. Immunol. Methods Section Abstract Doc Link 12738369 Disease Relevance 0 Pain Relevance 0.27
M3G was produced in the fetal lamb and accumulated extensively in fetal plasma and amniotic fluid.
Gene_expression (produced) of M3G in plasma
8) Confidence 0.03 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3183953 Disease Relevance 0.09 Pain Relevance 0.72
CONCLUSION: In this small pilot study, it appears that the serum levels of metabolites M3G and H3G do not correlate with myoclonus.


Gene_expression (levels) of M3G
9) Confidence 0.03 Published 2010 Journal J Opioid Manag Section Body Doc Link 20481173 Disease Relevance 0.06 Pain Relevance 0
Additionally, tetrodotoxin (Na(+) channel blocker), baclofen (gamma-aminobutyric acid(B) agonist), MVIIC (P/Q-type calcium channel blocker), and nifedipine (L-type calcium channel blocker) all abolished M3G-induced increases in [Ca(2+)](CYT), suggesting that M3G may produce its neuro-excitatory effects by modulating neurotransmitter release.
Gene_expression (produce) of M3G associated with tetrodotoxin, neurotransmitter, calcium channel and agonist
10) Confidence 0.02 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12873944 Disease Relevance 0.24 Pain Relevance 0.96
Morphine, M3G and M6G were determined in plasma and urine by high-performance liquid chromatography.
Spec (determined) Gene_expression (determined) of M3G in plasma associated with morphine
11) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262341 Disease Relevance 0.23 Pain Relevance 0.99
M3G was also detected but was below the lower limit of quantitation.
Gene_expression (detected) of M3G
12) Confidence 0.01 Published 2004 Journal J Pain Symptom Manage Section Abstract Doc Link 15120772 Disease Relevance 0.49 Pain Relevance 1.45
Heparin had no effect on M, M6G or M3G, whereas citrate in a glass tube produced consistently lower concentrations of M, M3G and M6G.
Gene_expression (produced) of M3G in tube
13) Confidence 0.01 Published 1989 Journal Ann. Clin. Biochem. Section Abstract Doc Link 2729862 Disease Relevance 0 Pain Relevance 0.32
The rectal administration resulted in less production of M3G and M6G.
Gene_expression (production) of M3G
14) Confidence 0.00 Published 1999 Journal Ther Drug Monit Section Abstract Doc Link 10217341 Disease Relevance 0.08 Pain Relevance 0.79
Morphine administration to neonatal guinea pigs produces measurable plasma and brain levels of M6G and M3G.
Gene_expression (levels) of M3G in plasma associated with morphine
15) Confidence 0.00 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965704 Disease Relevance 0.30 Pain Relevance 0.50
Morphine administration to neonatal guinea pigs produces measurable plasma and brain levels of M6G and M3G.
Gene_expression (produces) of M3G in plasma associated with morphine
16) Confidence 0.00 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965704 Disease Relevance 0.31 Pain Relevance 0.50
Morphine, M3G and M6G were determined in plasma and urine by high-performance liquid chromatography.
Spec (determined) Gene_expression (determined) of M3G in urine associated with morphine
17) Confidence 0.00 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262341 Disease Relevance 0.23 Pain Relevance 0.99
Morphine administration to neonatal guinea pigs produces measurable plasma and brain levels of M6G and M3G.
Gene_expression (levels) of M3G in brain associated with morphine
18) Confidence 0.00 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965704 Disease Relevance 0.30 Pain Relevance 0.50
Morphine administration to neonatal guinea pigs produces measurable plasma and brain levels of M6G and M3G.
Gene_expression (produces) of M3G in brain associated with morphine
19) Confidence 0.00 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965704 Disease Relevance 0.31 Pain Relevance 0.50

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