INT225167

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 13 5.00 Very Low Very Low Very Low
narcan 9 5.00 Very Low Very Low Very Low
opioid receptor 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Endogenous opioid 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 29 100.00 Very High Very High Very High
Papillomavirus Infection 1 98.36 Very High Very High Very High
Cervical Cancer 1 96.84 Very High Very High Very High
Apoptosis 139 92.64 High High
Pancreatic Cancer 35 41.04 Quite Low
Cancer 20 25.88 Quite Low
Infection 26 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OGF treatment does not change total Rb protein but decreases the amount of phosphorylated Rb
Negative_regulation (decreases) of Rb Binding (amount) of associated with retinoblastoma
1) Confidence 0.34 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.70 Pain Relevance 0
RBBP6 has been shown to bind p53, inhibit adenoviral E1A from binding pRb, and may have a ubiquitin-like domain [72].
Negative_regulation (inhibit) of pRb Binding (binding) of
2) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.55 Pain Relevance 0

General Comments

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